Autoimmune hemolytic anemia is a rare disease characterized by the appearance of anti-erythrocyte autoantibodies and subsequent destruction red blood cells immune system. The mechanisms erythrocytes loaded with are well studied; however, initial that trigger production antibodies to own antigens remain unclear. In pathogenesis autoimmune anemia, an important role played impaired immunological t...

Hemolytic anemia is a condition when there is a decreased number of erythrocyte in the circulation due to premature destruction. Mucosal pallor, jaundice, and paresthesia may appear as the oral manifestations of hemolytic anemia. Case presentation: A 48-year-old man came to oral medicine clinic with complaint of discomfort and spontaneous bleeding from a bump on the left of his tongue. Bruises ...

Although all blood cells are derived from hematopoietic stem cells, the regulation of this production system is only partially understood. Negative feedback control mediated by erythropoietin and thrombopoietin regulates erythrocyte and platelet production, respectively, but the regulation of leukocyte levels is less well understood. The local regulatory mechanisms within the hematopoietic stem...

BACKGROUND Interleukin-17A is the signature cytokine of the Th17 subset and drives inflammatory pathology, but its relevance to autoantibody-mediated diseases is unclear. Th1 cells secreting interferon-γ have been implicated in autoimmune hemolytic anemia, so the aim was to determine which cytokine is more closely associated with disease severity. DESIGN AND METHODS Interferon-γ and interleuk...

Drug-induced immune hemolytic anemia (DIIHA) is rare; it can be mild or associated with acute severe hemolytic anemia (HA) and death. About 125 drugs have been implicated as the cause. The HA can be caused by drug-independent antibodies that are indistinguishable, in vitro and in vivo, from autoantibodies causing idiopathic warm type autoimmune hemolytic anemia (AIHA). More commonly, the antibo...

introduction methylene blue was first described for the treatment of methemoglobinemia but practical usage of the compound for surgical purpose is common. the aim of this report is to describe a case of hemolysis in neonatal period as a potential hazard of methylene blue toxicity without presence of g6pd deficiency. case presentation in october 2015, a 36-week ga female infant with 2.05 kg weig...

The number of platelets in the peripheral blood of healthy children, full-term, and premature infants falls into the same range as that of adults. Thrombocytopenia, defined as a platelet count of less than 150,000/mm(<150 × 10/L), may be due to decreased production, splenic sequestration, or increased platelet destruction. The following is a review of disorders involving the last mechanism, all...