Eosinophils are recruited to the airways during allergic reactions, but animal models have shown that their mere presence is not sufficient for the development of bronchopulmonary hyperreactivity. Other factors, such as immunoglobulin (Ig)E, seem to be required. Using mice selected for the production of large amounts of IgE, the effects of antibody neutralization of IgE on antigen-induced lung ...

Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pulmonary vascular remodeling. Immunoglobulin E (IgE) known to participate in aortic remodeling, but whether IgE mediates unknown. In the present study, we found serum elevation arterial (PAH) patients, hypoxia-induced PH mice and monocrotaline-induced rats. Neutralizing with an anti-IgE antibody was effective prev...