نتایج جستجو برای: immunoglobulin gene
تعداد نتایج: 1191465 فیلتر نتایج به سال:
Regulated assembly of antigen receptor gene segments to produce functional genes is a hallmark of B- and T-lymphocyte development. The immunoglobulin heavy-chain (IgH) and T-cell receptor beta-chain genes rearrange first in B and T lineages, respectively. Both loci require two recombination events to assemble functional genes; D-to-J recombination occurs first followed by V-to-DJ recombination....
This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Poleta) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polkappa, an enzyme of the same polymerase family, used as a substitute ...
English version of this article has been published in “ journal of diabetes & metabolic disorders “ with both editor-in-chiefs agreement; aims to be available for Persian language readers; http://doi.org/10.1111/j.1399-039.2007.00956.x.
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