Sinonasal glomangiopericytoma is defined as a low-grade malignant tumor demonstrating perivascular myoid phenotype. We report case of sinonasal having diffuse architecture with bland spindle cells arranged in short fascicles, storiform, whorled, reticular pattern, separated by vascular plexus ranging from capillaries to large patulous spaces. Immunohistochemistry required differentiate it other...

Keratocystic odontogenic tumor (KCOT) is a benign intraosseous neoplasm of the jaw occurring most commonly in mandibular ramus molar area with male predilection. Peripheral KCOTs are very uncommon. Here we report a case of keratocyst in buccal mucosa in a 55 years old female patient, the diagnosis of which was based on subjective histological evaluation and further confirmed by immunohistochemi...

Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading to hair follicle destruction and irreversible alopecia. However, they are different in pathogene...

Clinical and immunohistochemical findings of splenic mast cell tumour in a cat: A case report | S Lee, MS Kang, Y Jeong, Kim, HH Kwak, EW Choi, I Park, JY Chung, JH JO Ahn Agricultural Journals

OBJECTIVES Present study was performed in order to uncover new aspects for nicotine-induced damages on spermatogenesis cell lineage. MATERIALS AND METHODS For this purpose, 36 mature male Wistar rats were divided into three groups as; control-sham (0.2 ml, saline normal, IP), low dose (0.2 mg/kg BW-1, IP) nicotine-received and high dose (0.4 mg/kg BW-1, IP) nicotine-received groups. Following...

BACKGROUND Treatment for patients with breast cancer (BC) is guided by human epidermal growth factor receptor 2 (HER2) status. The patient's HER2 status is assessed using US Food and Drug Administration-approved in vitro diagnostic (IVD) immunohistochemical (IHC) tests and laboratory-developed IVD tests. We analysed HER2 testing accuracy using data from the Nordic Immunohistochemistry Quality C...

Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) epen...

Frozen sections (FS) of tumor samples represent a cornerstone of pathological intraoperative consultation and have an important role in the microscopic analysis of specimens during surgery. So far, immunohistochemical (IHC) stainings on FS have been demonstrated for a few markers using manual methods. Microfluidic technologies have proven to bring substantial improvement in many fields of diagn...

Despite controversy on the correlation between p53 accumulation and TP53 mutational status, immunohistochemical (IHC) detection of overexpressed protein has long been used as a surrogate method for mutation analysis. The aim of our study was to characterise the IHC expression features of TP53 somatic mutations and define their occurrence in human cancers. A large-scale database analysis was con...

Periplaneta americana extracts (PAEs) play a crucial role in skin wound healing. However, their molecular effects and signaling pathways in regenerating tissues and cells are not clear. In this study, we refined the PAE from Periplaneta americana to investigate the mechanisms underlying skin wound healing. The human keratinocyte line HaCaT was selected and a mouse model of deep second-degree th...