the present study was designed to investigate the immunomodulatory activity of the ethanolic extract of tinospora cordifolia (family: menispermaceae)stem (climbing shrub, mango plant) at cellular level. for antioxidant study, the liver mitochondria were separated and the concentration of enzymes like lipid peroxidation (lpo), reduced glutathione (gsh), catalase (cat) and superoxide dismutase (s...

• ART possesses anti-complement bioactivities. is involved in three effector pathways of complement interception. targets C1q likely via binding globular head region. specifically binds to the key therapeutic C1q, C3 and C5. A modified ELISA selectively allows activation. Complement an important innate immune defence machinery. Once dysregulated, it often linked pathogenesis diverse autoimmune ...

Cordiceps sinensis is age old herb in traditional Chinese herbology. It has been widely researched. It is true Rasayan (Rejuvenator / Antiaging ) herb as it is immunomodulator, adaptogen, antioxidant, anti-cancer, neuroprotective, nootropic, aphrodisiac and hepatoprotective. Additionally it protects kidney, GIT , provides stamina and relieves fatigue. This review is an abridged version as the v...

Abstract Background The case fatality rate of patients hospitalized with COVID-19 is estimated at 13-17% higher rates in the critically ill (37-45%). Attenuation inflammatory cascade has potential to reduce mortality. purpose this retrospective cohort study was evaluate risk factors for 30-day all-cause mortality who received tocilizumab or baricitinib. Methods This a first 100 that each medica...

Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. Thes...

Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidenc...