نتایج جستجو برای: immunostimulating effects

تعداد نتایج: 1566132  

Journal: :FEMS Immunology & Medical Microbiology 1997

2015
Renata Ursu Sophie Taillibert Claire Banissi Eric Vicaut Olivier Bailon Emilie Le Rhun Jean-Sebastien Guillamo Dimitri Psimaras Annick Tibi Adama Sacko Athina Marantidou Catherine Belin Antoine F Carpentier

TLR-9 agonists are immunostimulating agents that have antitumor effects in animal models. A phase I trial was conducted to define the safety profile of subcutaneous injections, combined with intrathecally administration of CpG-28, a TRL 9 agonist, in patients with neoplastic meningitis (NM). Cohorts of 3-6 patients with NM were treated for 5 weeks with escalating doses of CpG-28. The primary en...

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