background due to a recent alarming increase in the number of hiv-hcv co-infected patients in romania. objectives a cross sectional study was conducted to assess the baseline predictors of liver disease evolution. patients and methods 83 hiv-hcv co-infected patients, untreated for hcv infection, were evaluated for viral replication, liver fibrosis (estimated by a noninvasive marker - fib4), and...

Abstract Background and Aims Longer survival in renal transplantation means an increase the number of patients who return to dialysis after graft loss. There is little literature about management immunosupression(IS) these complications derived from its maintenance withdrawal/reduction. Method We conducted a retrospective study involving cohort returned failure at Doce de Octubre Hospital 2015 ...

Background: Macrophage activation syndrome (MAS) is a severe life-threatening complication of the systemic-onset juvenile idiopathic arthritis (soJIA). The treatment options included high-dose corticosteroids (CS), cyclosporine A (CsA), intravenous immunoglobulin (IVIG) and biologics, predominantly IL-1 antagonist – anakinra. In Russia anakinra has not approved yet, so canakinumab (CAN) single ...

Background: Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA). Usually uveitis developed during first two years after occurred [1]. In previous studies was shown shorter time interval between and severe course observed [2]. Information about before scarce. Objectives: We aimed to evaluate clinical features therapy JIA-associated uveitis, which joint...

Slavin et al. in [1976], were the first to found that rejection of skin and heart allograft was greatly delayed in rodents treated with Total Lymphoid Irradiation (TLI). Since 1980, the immunosupression of TLI has been applied in transplants and autoimmune diseases. However, the development of immunosuppressive drugs decreased the use of radiotherapy for immunosuppressive finality except for th...

Pathogenesis of acute respiratory distress syndrome Damage-associated DNA and microparticles Cell-free DNA is detected in blood in many diseases and can originate from necrotic cells or apoptotic processes to refl ect the extent of cellular damage. ARDS is associated with several acute diseases that may cause cell death and release of DNA into the bloodstream [1]. Okkonen and colleagues [2] per...

Corresponding Author: Antonio Biondi, MD; e-mail: [email protected] Dear Editor, Each year, tens of millions of people around the world are diagnosed with cancer, and more than half of them die from it1. The causes of cancers are understood to be mainly tobacco smoking – especially for lung cancer2-4, dietary factors, and infection/chronic inflammation, each of these accounting for up to one thir...

This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Following a recent report, the median age for patients with confirmed H7N9 virus infection is 61 years old with 42.3% of patients being 65 years of age or older [1]. A total of 61.3%...

Cryptococcosis is known as a central nervous system infection which is caused by Cryptococcus neoformans (C. neoformans). The contamination is made by inhaling the fungi, then it produces the first lesion in the lung tissue. This phase is non symptomatic. In debilitated people, the infection disseminates and affects the meninges. The AIDS patients are the most affected group, and the disseminat...

The current diagnostic techniques are not effective in key areas of tuberculosis (TB) research, such as predicting susceptibility, treatment outcome, and monitoring the effectiveness of drug or vaccine trials. Hence, more emphasis is to be placed on biomarker research. A biomarker is a characteristic feature that is objectively measured and evaluated as an indicator of a biological or pathologi...