OBJECTIVE Increasing rates of type 2 diabetes worldwide suggest that diabetes may be caused by environmental toxins. Cadmium is a widespread environmental pollutant that accumulates in the pancreas and exerts diabetogenic effects in animals. To test the hypothesis that exposure to cadmium is associated with impaired fasting glucose and type 2 diabetes, we examined the associations between urina...

OBJECTIVE Fibroblast growth factor 19 (FGF19), a hormone secreted from the small intestine, has recently been shown to stimulate glycogen synthesis and inhibit gluconeogenesis through insulin-independent pathways. This study investigated the change of FGF19 in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM) and explored the association of serum FGF19 levels with parameters of gl...

BACKGROUND Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absorption and bioactivity, and bioconversion diminishes the toxicity of red ginseng's metabolite. This study was conducted to investigate the effects of daily supplementation with f...

Thirty-two subjects with impaired fasting glucose (IFG) and 28 subjects with normal fasting glucose (NFG) ingested a labeled meal and 75 g glucose (oral glucose tolerance test) on separate occasions. Fasting glucose, insulin, and C-peptide were higher (P < 0.05) in subjects with IFG than in those with NFG, whereas endogenous glucose production (EGP) did not differ, indicating hepatic insulin re...

OBJECTIVE To recognize the prevalence of impaired fasting glucose level (IFG) and impaired glucose tolerance (IGT) in general population of Depok Area, West Java. METHODS the study was conducted in a population with age > or = 25 years, in Depok Area, West Java, which was selected by using two stage random sampling. Data were collected by using the Step Wise Approach of WHO. Subjects without ...

OBJECTIVES  To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality. DESIGN  Meta-analysis of prospective cohort studies. DATA SOURCES  Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA  Prospective cohort studies from general populations were included for meta-analysis if they reporte...

background: in 2-4% of couples in fertile ages, recurrent pregnancy loss (rpl) occurs which consisted one out of 300 pregnancies. the aim of this study was to comparison insulin resistance (ir) in patients with rpl to normal individuals. materials and methods: in a case-controlled, prospective study, 49 non-pregnant, non-diabetic women with early rpl as the case group and 49 non-pregnant, non-d...

BACKGROUND Pre-diabetes and untreated diabetes are common in patients with peripheral artery disease however their impact on outcome has not been evaluated. We examined the association of impaired fasting glucose, diabetes and their treatment with the presentation, mortality and requirement for intervention in peripheral artery disease patients. METHODS We prospectively recruited 1637 patient...

OBJECTIVE To investigate the association between lifestyle risk factors and impaired fasting glucose level. METHODS The large-scale, community-based, cross-sectional study was conducted in 2012 in Ilam province, Iran, and comprised 150 impaired fasting glucose cases and 450 controls. Face-to-face interviews were conducted using a standard lifestyle questionnaire, and subjects were checked for...

OBJECTIVES This longitudinal study investigated whether or not plasma retinol-binding protein (RBP), recently referred to as RBP4, was a marker of insulin resistance in overweight subjects. METHODS We measured anthropometric markers as well as RBP, fasting glucose and insulin in 206 overweight subjects and repeated these measurements 36 months later. Subjects were grouped according to fasting...