Central vein stenosis is a well-documented consequence of cardiovascular implantable electronic devices. In hemodialysis patients, where preserving venous real estate is crucial, use of subcutaneous implantable cardioverter-defibrillators (S-ICDs) remains controversial. We present a novel approach for implanting an S-ICD in a patient with endstage renal disease, central venous stenosis, and pre...

Circulation. 2017;135:593–608. DOI: 10.1161/CIRCULATIONAHA.116.025312 February 7, 2017 593 Anne M. Gillis, MD ABSRACT: Sex-specific differences in the epidemiology, pathophysiology, clinical presentation, clinical treatment, and clinical outcomes of atrial fibrillation (AF), sustained ventricular arrhythmias, and sudden cardiac death are recognized. Sex hormones cause differences in cardiac ele...

BACKGROUND Sudden death (SD) is a frequent catastrophic complication in patients after myocardial infarction. Circumstances of SD may affect strategies for prevention. METHODS AND RESULTS We reviewed source documentation for 1067 patients who had SD in the Valsartan in Acute Myocardial Infarction Trial (VALIANT) trial. We determined the circumstances of these events and assessed long-term mor...

BACKGROUND The impact of QRS morphology and duration on the effectiveness of cardiac resynchronization therapy (CRT) has been usually assessed separately. The interaction between these 2 simple ECG parameters and their effect on CRT has not been systematically assessed in a large-scale clinical trial. METHODS AND RESULTS The Resynchronization-Defibrillation for Ambulatory Heart Failure Trial ...

BACKGROUND In patients with implantable cardioverter-defibrillators, healthcare utilization (HCU) and expenditures related to shocks have not been quantified. METHODS AND RESULTS We performed a retrospective cohort study of patients with implantable cardioverter-defibrillators identified from commercial and Medicare supplemental claims databases linked to adjudicated shock events from remote ...

Background—Prospective studies defining the risk associated with pacemaker or implantable cardioverter-defibrillator replacement surgeries do not exist. These procedures are generally considered low risk despite results from recent retrospective series reporting higher rates. Methods and Results—We prospectively assessed predefined procedure-related complication rates associated with elective p...

BACKGROUND Prospective studies defining the risk associated with pacemaker or implantable cardioverter-defibrillator replacement surgeries do not exist. These procedures are generally considered low risk despite results from recent retrospective series reporting higher rates. METHODS AND RESULTS We prospectively assessed predefined procedure-related complication rates associated with elective...

BACKGROUND Previous studies have shown conflicting results regarding the benefit of cardiac resynchronization therapy (CRT) by sex and QRS duration. METHODS AND RESULTS In the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT), we evaluated long-term clinical outcome of heart failure (HF) or death, death, and HF alone by sex and QRS durat...

BACKGROUND A conceptualized model may be useful for understanding risk stratification of primary prevention implantable cardioverter defibrillators considering the competing risks of appropriate implantable cardioverter defibrillator shock versus mortality. METHODS AND RESULTS In a prospective, multicenter, population-based cohort with left ventricular ejection fraction ≤35% referred for prim...