Previous studies of CD8(+) T cell immunodominance after primary virus infection of F(1) mice compared with their inbred parents have generally concluded that no dramatic changes occur. In this study, we revisit this issue using vaccinia virus (VACV), which has a large genome, a recently defined immunodominance hierarchy in mice, and is a candidate vector for vaccines. We found that immunogenici...

P.40k INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 405 Homozygosity after eight generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 407 Homozygosity after fourteen generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

The Mongolian gerbil has been a useful laboratory animal in many research fields, especially in ischemia studies. However, due to the variation of the circle of Willis (COW), the ischemic model is unstable and various. To solve this problem, we newly established an inbred strain of gerbils, restricting breeding and keeping to F23. The data on the breeding and growth of the animals are described...

The generation of special crosses between different inbred lines such as recombinant inbred strains (RIS) and intermated recombinant inbred populations (IRIP) is being used to improve the power of QTL detection techniques, in particular fine mapping. These approaches acknowledge the fact that recombination of linked loci increases with every generation, caused by the accumulation of crossovers ...

The introduction of the use of inbred micc into cancer and other biological research has been a long and slow process. Even at the present time the application of this technic is not by any means universal. A glance at Hartwell 's recent extensive survey of compounds which have been tested for carcinogenic activity (13) will show that, a l t hough the use of inbred mice is largely appreciated, ...

the objective of the present study was to evaluate the genetic structure and diversity of 16 generations of native fowls of west azerbaijan province, iran using the pedigree data collected between 1994 and 2012. inbreeding coefficient (f), pedigree completeness index (pci), parameters of the probability of gene origin and other parameters related to the genetic structure were estimated using th...

Several inbred lines of rats were produced from noninbred stock of Dahl salt-sensitive (S) rats, and several inbred lines were also produced from noninbred stock of Dahl salt-resistant (R) rats. There were significant differences (p less than 0.001) in blood pressure response to a high salt diet among the inbred S lines produced, which indicates that the original S stock obtained from Brookhave...

The aim of the present study was to determine the impact of increased consumption of phytosterols or phytostanols on blood pressure and renal blood pressure regulatory gene expression in stroke-prone spontaneously hypertensive (SHRSP) and normotensive Wistar-Kyoto (WKY) inbred rats. SHRSP and WKY inbred rats (10/group) were fed a control diet or a diet supplemented with phytosterols or phytosta...

One of the great surprises of my first stay in the US during the fall of 1950 concerned the so-called "transplantable tumors" and their "immunology". During the first part of the 20th century, cancer researchers spoke about transplantable and non-transplantable tumors. The mice and rats were not inbred and transplantability therefore meant transgression of histocompatibility barriers, but most ...