Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM with particle size of 161±1.5 nm and polydispersity index of 0.172±0.01 were produced in <1 hour using a wet milling technology, Dena® DM-100. The crystallinity of the processed ARTM was confirmed using differential scanning calorimetry and powder X-ray d...

BACKGROUND/AIMS Hepatocellular carcinoma (HCC) also known as malignant hepatoma is a most common liver cancer. Doxorubicin (Doxo) is an anti-cancer drug having activity against a wide spectrum of cancer types. Clinical Utility of doxo has been limited due to its poor bioavailability and toxicity to heart and spleen. Furthermore, cancer chemotherapeutics have limited oral absorption. Transferrin...

Slope instability research and susceptibility mapping is a fundamental component of hazard management in decreasing the risk of living with landslides. Landslide susceptibility is defined as the proneness of the terrain to produce slope failures and susceptibility is usually expressed in a cartographic way. The Dena city in Iran is a landslide prone zone because of its own characteristics inclu...

Abstract. Permanasari I, Sulistyaningsih E, Kurniasih B, Indradewa D. 2023. Morphophysiological and yield traits of soybean varieties tolerant intercropping with maize. Biodiversitas 24: 3872-3880. Not all grow optimally when intercropped Previously, we identified seven (i.e., "Demas 1", Dena "Dena 2", "Derap "Devon "Wilis") two "Dega 1" "Mahameru") as intolerant based on selection indices yiel...

BACKGROUND The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate the possible role of Wnt signaling in hepato-carcinogenesis. METHODS Ninety rats were included in the study and were divided equally into: Control group, rats which received ...

An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been developed in rat liver using presumed preneoplastic lesions, foci of gamma-glutamyltranspeptidase (GGTase)-positive hepatocytes, as the endpoint. To evaluate the tumor-promoting activity of phenobarbital, rats were administered diethylnitrosamine (DENA), 2.0 mmole/kg, followed by 500 ppm phenobarbital in thei...