The objective of this study was to investigate the effect of inbreeding on lactation performance in Holstein cows of Iran.The pedigree file contained information of 1,025,281 animals born between 1965 and 2007.Lactation performance records from March 2000 to April 2009 comprising 193,501calving events on 123,751 cows in 85 dairy herds were included in the data set. The potential consequent effe...

UNLABELLED FSuite is a user-friendly pipeline developed for exploiting inbreeding information derived from human genomic data. It can make use of single nucleotide polymorphism chip or exome data. Compared with other software, the advantage of FSuite is that it provides a complete suite of scripts to describe and use the inbreeding information. It includes a module to detect inbred individuals ...

One problem in modern dogs is a high occurrence of physical diseases, defects and disorders. Many breeds exhibit physical problems that affect individual dogs throughout life. A potential cause of these problems is inbreeding that is known to reduce the viability of individuals. We investigated the possible correlation between recent inbreeding and health problems in dogs and used studbook data...

Data from four closely related Line 1 Hereford herds were used to estimate variance components and predict EPD for birth weight (BWT), weaning weight (WWT), and postweaning gain (PWG). Herds were located in diverse environments and differed in level of phenotypic performance. Within-herd BWT analyses considered effects of inbreeding of calf and dam, sex, age of dam (AOD), and contemporary group...

Genome elimination - whereby an individual discards chromosomes inherited from one parent, and transmits only those inherited from the other parent - is found across thousands of animal species. It is more common in association with inbreeding, under male heterogamety, in males, and in the form of paternal genome elimination. However, the reasons for this broad pattern remain unclear. We develo...

Studbook information collected from 1988 to 2011 in Jafarabad breeding station of Moghani sheep, north-west of Iran, related to 9,457 lambs were used to study the genetic diversity and to evaluate the effectiveness of an implemented rotational mating scheme using pedigree analysis. Lambs born during 2009-2011 were considered as reference population. Means inbreeding and average coancestry for t...

Associative overdominance, the fitness difference between heterozygotes and homozygotes at a neutral locus, is classically described using two categories of models: linkage disequilibrium in small populations or identity disequilibrium in infinite, partially selfing populations. In both cases, only equilibrium situations have been considered. In the present study, associative overdominance is r...

When close relatives are forced to reproduce, the resulting offspring inherit above average homozygosity and reduced fitness. Biologists now recognize inbreeding depression in the wild, a phenomenon that will probably increase as natural populations become depleted and fragmented. Inbreeding depression is most commonly expressed as compromised fertility and embryogenesis, but actual mechanisms ...

A classical paradigm in population genetics is that homozygosity or inbreeding affects individual fitness through increased disease susceptibility and mortality, and diminished breeding success. Using data from an insular population of mouflon (Ovis aries) founded by a single pair of individuals, we compare embryo number of ewes with different levels of inbreeding. Contrary to expectations, ewe...