Indomethacin is a clinically classical non-steroidal anti-inflammatory drug that has been marketed since 1965. The third polymorph, Form δ, was discovered by both melt and solution crystallization in 1974. δ-indomethacin cannot be cultivated as large single crystals suitable for X-ray crystallography and, therefore, its crystal structure not yet determined. Here, we report the elucidation of 3D...

Suppository diclofenac instead of intravenous meperidine for postoperative management

the potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. in this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. it is worth mentio...

hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. the high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. androgen effects on spatial memory are complex and contradictory. some evidence suggests a positive correlation between androgens and spatial memo...

Objective: To determine the effect of Induction early meconium evacuation using glycerin suppository in promoting feeding tolerance low birth weight infants. Methodology: This quasi-experimental study was conducted Department Neonatology at Pakistan Institute Medical Sciences (PIMS) Islamabad. A total 120 neonates were included both groups study. The control group received standard treatment, w...

Abstract Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects rat model of indomethacin-induced gastric ulceration. Fustin itself has been ethanol-induced ulcer. In present study we aimed to reveal effect flavonoid isolated from was purified. The experiment performed on 30 male Wistar rats allocat...

This research investigated the effect of Andrographis paniculata (AP) on oxidative stress following indomethacin-induced gastric ulcer in rats. A total 20 male albino Wistar rats (150-180g) used for this study were grouped into four (n=5): 1, Negative Control; 2, Positive Control and 3, test group treated with normal chow, 20mg/kg indomethacin, mg/kg indomethacin plus omeprazole at AP 16.7 resp...

Background and aims: Post-ERCP complications increase with repeated attempts at cannulation. We evaluated several advanced biliary cannulation techniques applied when the standard approach fails. Methods: In total, 1873 consecutive patients underwent ERCP at our institution during the period 2010 - 2014. Guidewire-assisted (GA) cannulation with no contrast injection until deep biliary cannulati...

The clinical anticonvulsant efficacy of single dose rectal and oral administration of diazepam 20 mg was examined in two double-blind placebo-controlled trials in adult epileptic patients. All subjects suffered from drug resistant epilepsy and frequently experienced serial seizures. Diazepam was administered rectally as a new experimental suppository formulation immediately after a seizure and ...