نتایج جستجو برای: indoxyl sulfate
تعداد نتایج: 58952 فیلتر نتایج به سال:
The action of colon microbes on undigested proteins gives rise to a variety of indoles and phenols that are conjugated by the liver before excretion by the kidney. Among the most abundant of the excreted compounds is indoxyl sulfate (IS), which was shown more than 100 years ago to accumulate in the blood when kidney function is lost (1,2). Because it is abundant and relatively easy to measure, ...
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP) was investigated. Membrane vesicles isolated from MRP4- or BCRP-overexpressing human embryonic kidney cells w...
Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues. Fibrosis is characterized by excessive production and deposition of extracellular matrix proteins with a detrimental impact on organ function. Another key feature of CKD is the retention and subsequent accumulation of solutes that are normally...
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