نتایج جستجو برای: infantile hemangioma
تعداد نتایج: 20859 فیلتر نتایج به سال:
Infantile hemangioma (IH) is a vascular tumor that begins with rapid vascular proliferation shortly after birth, followed by vascular involution in early childhood. We have found that NOTCH3, a critical regulator of mural cell differentiation and maturation, is expressed in hemangioma stem cells (HemSCs), suggesting that NOTCH3 may function in HemSC-to-mural cell differentiation and pathologica...
Infantile hemangioma (IH) is the most common tumor of infancy. Its cellular origin and biological signals for uncontrolled growth are poorly understood, and specific pharmacological treatment is unavailable. To understand the process of hemangioma-genesis we characterized the progenitor hemangioma-derived stem cell (HemSC) and its lineage and non-lineage derivatives. For this purpose we perform...
Hemangiomas constitute a heterogeneous group of benign vascular proliferations. Their pathogenesis is not completely understood. In this study the expression of GLUT-1, VEGF, Ki-67, bcl-2 and apoptotic index in twenty-six cases of infantile capillary hemangioma (ICH), fifteen of lobular capillary hemangioma (LCH) and nine of epithelioid hemangioma were examined. The expression of GLUT-1 was con...
Recent advances in the understanding of the metastatic phenomenon in cancer have led to the description of a metastatic niche. This concept describes a site prepared for the tumor cells in areas frequently associated with metastasis for the individual tumor studied. This niche is a "soil" that allows for the tumor cell or "seed" to lodge and grow. Certain aspects of the biology of infantile hem...
Propranolol has emerged as a new treatment option for infantile hemangiomas. We describe a 20-month-old boy with a large right parotid hemangioma diagnosed at the age of 37 days. Starting at the age of 2.5 months, he received oral propranolol for 6.5 months. Although the mass regressed, it recurred when propranolol was discontinued. He was successfully retreated at the age of 11 months with pro...
Objective. To analyze the treatment results of patients with infantile hemangiomas using various methods. Methods. The study is grounded on children (n=189) during period 2000-2018 years. All were divided into groups: 1) dynamic observation - 23 (12.2%) children; 2) local destruction 78 (41.3%); 3) surgical 22 (11.6%); 4) drug therapy 66 (34.9%) patients. interstitial coagulation (n=28) and ele...
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