OPTIMAL ANTI-INFECTIVE DRUG DOSES FOR CHILDREN Anti-infective agents are among the most commonly prescribed drugs in children. What is considered the optimal dose of an anti-infective agent is determined by how the child handles the drug and the resulting drug concentration in the body (pharmacokinetics, PK) as well as by the effect of the drug on the target pathogen (pharmacodynamics, PD). Amo...

Ischemic stroke is a serious neurological complication of infective endocarditis. Intravenous tissue plasminogen activator (t-PA), which has only been approved for treatment of hyperacute stroke, has been excluded as an ischemic stroke treatment due to infective endocarditis according to current expert consensus guidelines. Here, we describe a case of a hyperacute stroke patient treated with in...

BACKGROUND AND OBJECTIVE The patient package insert is an important source of drug information. The aim of this study was to evaluate and compare the PPI of the anti-infective agents manufactured in Palestine with the imported equivalents. METHOD The selection criteria generated 15 different anti-infective agents available as 36 locally manufactured products and 15 imported equivalents. The d...

A young man is reported with recurrent Staphylococcus aureus joint sepsis associated with dermatomyositis. His dermatomyositis failed to resolve on treatment with antimicrobial agents alone, indicating that if staphylococcal infection was the triggering event for the dermatomyositis then the subsequent process was apparently self perpetuating, requiring cytotoxic agents for its control. This ca...

THE CONCEPT of intestinal antisepsis is not new. I t was under taken without success in the preceding century. Not unti l 1941,20 with the discovery of succinylsulfathiazole, was a practical intestinal antiseptic available. T h e sulfa drugs are bacteriostatic-not bactericidal--agents. Consequently, they must be administered for a considerable period of t ime and the resident organisms must be ...