context patients with hepatic dysfunction suffer from many problems and associated complications in organs other than the liver. therefore, it is very important to investigate the effects of different drugs in the treatment of these patients. due to the high consumption of non-steroidal anti-inflammatory drugs (nsaids), studying the effects of these drugs in patients with hepatic dysfunction is...

IL-1β is one of the important IL-1 superfamily cytokines that shows crucial role in pathogenesis various inflammatory disorders like osteoarthritis, epidermolysis bullosa, psoriasis and type II diabetes. Dugs with IL-1βinhibitory effect can show promising results these types disorders. Diacerein its active metabolite rhein prevent generation are consequently used to treat conditions such as pso...

chronic inflammatory demyelinating polyneuropathy is an autoimmune disease with progressive and relapsing courses. the main clinical presentations are diffuse deep tendon hyporeflexia or areflexia and symmetric proximal-distal muscles weakness. myasthenia gravis is also an immune mediated disease with fluctuating ocular and bulbar symptoms and sometimes weakness. although both myasthenia gravis...

Objective: Triptolide, the active component of Tripterygium wilfordii Hook F has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional Chinese medicine. However, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. In this review, we discuss the autoimmune disorders and inflammatory condition...

eosinophilic gastroenteritis (ege) is a rare inflammatory disorder of gastrointestinal tract characterized by eosinophilic infiltration of the bowel wall. it can mimic many gastrointestinal disorders due to its wide spectrum of presentations. diagnose is mostly based on excluding other disorders and a high suspicion. here we report a case of 26 year old man with a history of sever epigastric pa...

INTRODUCTION Ulcerative colitis (UC) and Crohn’s disease (CD) are idiopathic conditions that primarily affect the gastrointestinal tract, but also are associated with a variety of systemic or extra-intestinal manifestations. These extra-intestinal manifestations may implicate multiple organ systems. For some of these disorders there is evidence that the severity and duration of the inflammatory...

Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in oth...

The Cesarean section rate has been steadily rising in United States from 4.5% in 1965 [1] to nearly 33% [2] in 2010. In developing countries, such as China and Brazil, this number accounts for 40% and 45% [3], respectively. The high prevalence of the condition compared to the number of women in need of c-section (5 to 10%) suggests that the difference of approximately 30% is only a socio-econom...

Background: Systemic and local inflammatory responses have been proposed as mechanisms in the initiation and progression of dementia. Several studies described increased levels of proinflammatory cytokines in Alzheimer's disease patients. Acute phase reactants such as CRP have been detected within the neuritic plaques and neurofibrillary tangles in the brains of patients with Alzheimer's diseas...

Antineutrophil cytoplasmic antibodies (ANCAs) constitute a new class of autoantibodies that seem to recognise myeloid lysosomal enzymes. The occurrence of ANCAs with specificity for human leucocyte elastase (HLE) was assessed in serum samples that were routinely submitted for ANCA determination. During a study period of more than six years anti-HLE was found in only six out of 1102 serum sample...