Noncompliance with study medications is an important issue in the design of endpoint clinical trials. Including noncompliant patient data in an intention-to-treat analysis could seriously decrease study power. Standard methods for calculating sample size account for noncompliance, but all assume that noncompliance is noninformative, i.e., that the risk of discontinuation is independent of the r...

background: using primary tumor gene expression has been shown to have the ability of finding metastasis-driving gene markers for the prediction of breast cancer recurrence (bcr). however, there are some difficulties associated with the analysis of microarray data which led to poor predictive power and inconsistency of the previously introduced gene signatures. methods: in this study a hybrid m...

We propose several novel criteria for the selection of groups of jointly informative continuous features in the context of classification. Our approach is based on combining a Gaussian modeling of the feature responses, with derived upper bounds on their mutual information with the class label and their joint entropy. We further propose specific algorithmic implementations of these criteria whi...