PURPOSE To investigate the optimal strategy for surgical management of traumatic cataract with posterior capsular rupture. METHODS We describe four cases of traumatic cataract with posterior capsular rupture and an in vitro model built to evaluate the optimal infusion pressure during surgery. RESULTS All patients underwent cataract surgery. By using an anterior chamber maintainer to elevate...

We hypothesized chemotherapy infusion related reaction might be predictable according to continuous monitoring of heart rate recorded by a wearable device. In this study we propose deep learning model that predicts patient level symptoms per minute during infusion. prospectively enrolled patients with cancer who will receive and at high risk for reaction. During infusion, 1 interval was from sm...

Abstract Intravenous (IV) anti-CD20 monoclonal antibody (mAb) therapy for chronic lymphocytic leukemia (CLL) patients often produces a first dose infusion reaction (FDIR) within the 2 h that requires careful monitoring to avoid serious complications and fatalities. To better understand FDIR, we studied blood samples collected from 37 treatment-naïve CLL in our clinical trial NCT03788291 undergo...

We have been developing a therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells (BMSCs). Before human clinical trials can be considered, the safety and efficacy of BMSC infusion in medium to large animals must be confirmed; thus, we developed a canine liver fibrosis model. A small amount of bone marrow fluid was aspirated from the canine humerus to ass...

conclusions ia fluid resuscitation is superior to iv resuscitation in hemorrhagic shock induced cardiac arrest. results while iv rl infusion failed to restore chest motion in mice (n = 5), ia rl infusion restored chest motion in all mice examined (n = 6) (p = 0.0067). in three mice, iv rl infusion after cardiac arrest showed no effect on cc. after failure of venous infusion, ia rl infusion was ...

BACKGROUND Therapeutic hypothermia during operation decreases postoperative intra-abdominal adhesion formation. We sought to determine the most appropriate duration of hypothermia, and whether hypothermia affects the expression of tissue plasminogen activator (tPA). METHODS 80 male BALB/c mice weighing 25-30 g are randomized into one of five groups: adhesion model with infusion of 15°C saline...

OBJECTIVE Diabetes mellitus is a risk factor for death after coronary artery bypass grafting. Its relative risk may be related to the level of perioperative hyperglycemia. We hypothesized that strict glucose control with a continuous insulin infusion in the perioperative period would reduce hospital mortality. METHODS All patients with diabetes undergoing coronary artery bypass grafting (n = ...

PURPOSE In order to identify methods for preventing phlebitis caused by intravenous administration of vinorelbine (VNR), we established a procedure for estimating the severity of phlebitis in an animal model. METHODS Four different factors (administration rate, dilution, flushing, and infusion of fat emulsion) were evaluated for alleviation of phlebitis caused by VNR infusion. VNR was diluted...