نتایج جستجو برای: inha
تعداد نتایج: 590 فیلتر نتایج به سال:
1 2 3 Persistent Detrusor Overactivity in Rats after 4 Relief of Partial Urethral Obstruction 5 6 Long-Hu Jin, Karl-Erik Andersson, Jeong-Uk Han, Yong-Hyun Kwon, Chang-Shin 7 Park, Hwa-Yoan Shin, Sang-Min Yoon, Tack Lee 8 Departments of Urology, Anesthesiology and Pharmacology, Inha University College 9 of Medicine by BK 21 project, Incheon, Korea; and Wake Forest Institute for 10 Regenerative ...
An oligonucleotide chip (Combichip Mycobacteria chip) detecting specific mutations in the rpoB, katG, and inhA genes of Mycobacterium tuberculosis was compared with conventional antimicrobial susceptibility results. The probes detecting drug resistance were as follows: 7 wild-type and 13 mutant probes for rifampin and 2 wild-type and 3 mutant probes for isoniazid. Target DNA of M. tuberculosis ...
OBJECTIVE To investigate the frequency of mutations in catalase-peroxidase and inhibin alpha genes in clinical isolates of isoniazid resistant Mycobacterium tuberculosis strains. METHODS The study was conducted at Provincial Tuberculosis Reference Laboratory, Peshawar, Pakistan, from April 2015 to March 2016, and comprised sputum specimens obtained from patients of different ages. All the iso...
A 15437 bp region encompassing the inhA locus from the Mycobacterium avium chromosome was cloned and sequenced. From the sequencing data generated and the results of homology searches, the primary structure of this region was determined. This region contains four known genes (acnA, fabG, inhA and hemH) and two genes, invA and invB, whose products display homology with p60 invasion protein of Li...
The natural product Agelasine F found in marine sponge Agelas sp. along with the known inhibitors of the target enzymes in Mycobacterium tuberculosis (Mtb), and the first-line tuberculosis (TB) drugs have been docked to enoyl reductase (InhA), Isoniazid-resistant I21V and S94A enoylACP (COA) reductase mutant enzymes, 7,8-diaminopelargonic acid synthase (DAPAS), pantothenate synthetase (PS), and...
This study aims to evaluate the clinical value of PCR-fluorescent probes for detecting mutation gene associated with extensively drug-resistant tuberculosis (XDR-TB). The molecular species identification 900 sputum specimens was performed using polymerase chain reaction (PCR)–fluorescent probe. mutations drug resistance genes rpoB, katG, inhA, embB, rpsL, rrs, and gyrA were detected. convention...
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of isoniazid resistance is linked to mutations in the pro-drug activating enzyme KatG, so the discovery of direct inhibitors (DI) of the enoyl-ACP r...
BACKGROUND The objectives of the study were to compare the performance of line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis of multidrug resistant tuberculosis (MDR-TB), and to study the mutation patterns associated with rpoB, katG and inhA genes at a tertiary care centre in north India. METHODS In this cross-sectional study, 269 previously treated sputum-...
BACKGROUND Tuberculosis (TB) incidence and mortality are declining worldwide; however, poor detection of drug-resistant disease threatens to reverse current progress toward global TB control. Multiple, rapid molecular diagnostic tests have recently been developed to detect genetic mutations in Mycobacterium tuberculosis (Mtb) genes known to confer first-line drug resistance. Their utility, thou...
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