Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine...

A method for diagnosing the physical properties of a time-varying ellipse is presented. This essentially involves extending the notion of instantaneous frequency to the bivariate case. New complications, and possibilities, arise from the fact that there are several meaningful forms in which a time-varying ellipse may be represented. A perturbation analysis valid for the near-circular case clari...

BACKGROUND Because corneal infiltrative events (CIEs) may result from bacterial components on contact lenses, which can come from contaminated lens cases, we evaluated the biocidal efficacy of five multipurpose solutions against Gram-negative commonly isolated and CIE-associated organisms. METHODS Of the multipurpose solutions tested, one contained polyhexamethylene biguanide (PHMB)/polyquate...

In left-right symmetric seesaw models an eight-fold degeneracy among the right-handed neutrino mass matrices is known to exist. We use stability and viability of leptogenesis as criteria in order to discriminate among the degenerate solutions and to partially lift the eight-fold degeneracy. PACS. 98.80.Cq Particle-theory and field-theory models of the early Universe – 14.60.Pq Neutrino mass and...

In this talk, we introduce the character degree graph of a finite group G. We will discuss various properties of this graph, and we will further discuss what graphs can occur as the character degree graphs of finite solvable groups. In particular, we focus on groups with characters of degree pq, pr, and qr, where p, q, and r are distinct primes. Although some group theory will be assumed, knowl...

The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD). Furthermore, case-control studies report that individuals with genetic variants in the dopamine transporter (DAT, SLC6A) have a higher PD risk when exposed to PQ. However, it remains a topic of debate whether PQ can enter dopamine (DA) neurons through...

In order to detect grid harmonic and reactive current precisely and real time, this paper arrived at a method of harmonic and reactive current real-time detection applied to active power filter based on the three-phase circuit instantaneous reactive power theory. With Matlab simulation software, researches on simulation of harmonic detection means are carried out, and an analysis of the simulat...

Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has been reported to be an immunotoxic agrochemical compound. PQ was shown to decrease the number of macrophages in rats and suppress monocyte phagocytic activity in mice. Howeve...

This paper presents inventory models for perishable items with stock dependent selling rate. The selling rate is assumed to be a function of current inventory level and rate of deterioration is taken to be constant. Under instantaneous replenishment with zero lead time, the model incorporates aspects such as complete, partial, and no backlogging. EOQ is determined for maximizing the total profi...

A generalised instantaneous non-active power theory is presented. Comprehensive definitions of instantaneous active and non-active currents, as well as instantaneous, average and apparent powers, are proposed. These definitions have flexible forms that are applicable to different power systems, such as single-phase or multi-phase, periodic or non-periodic and balanced or unbalanced systems. By ...