Diabetes mellitus is a hereditary, chronic disorder in the endocrine system that constitutes a major public health problem throughout the world [1]. It is characterized by absolute or relative deficiencies in insulin secretion and/ or insulin action associated with chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism [2,3]. As a consequence of the metabolic deran...

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

Insulin concentrations in humans continuously change and typically increase only when glucose also increases such as with eating. In this setting, it is not known whether the severity of hepatic and extrahepatic insulin resistance is comparable and whether the ability of glucose to regulate its own uptake and release is defective in non-insulin-dependent diabetes mellitus (NIDDM). To address th...

Type 1 Diabetes Mellitus, also known as insulin-dependent diabetes mellitus (IDDM), is a chronic disease caused by the autoimmune destruction of pancreatic β cells, which function insulin-producing cells. This study was aimed to assess level knowledge about T1DM and adherence medications prescribed patients at two different tertiary hospitals in Malaysia. hospital-based cross-sectional conducte...

Understanding the management of non-insulin-dependent (type 2) diabetes (NIDDM) requires the grasp of three concepts. Firstly, the condition is steadily progressive and demands appropriate changes of therapy over time. Secondly, therapeutic aims must be set for three parameters: plasma lipids, plasma glucose and blood pressure. Thirdly, the condition is dangerous and regular screening for early...

OBJECTIVE We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed from the Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS interval...

Much of the public media discussion of genetics of common diseases has centered on opportunities for targeted preventive actions. At the same time, in the specialist literature, there has been extensive discussion of ‘‘interaction,’’ both between genes and between genes and environment. These two topics concern the use and interpretation of statistical models for risk of diseases with several, ...

BACKGROUND Successful management of diabetes requires attention to the behavioural, psychological and social aspects of this progressive condition. The Diabetes MILES (Management and Impact for Long-term Empowerment and Success) Study is an international collaborative. Diabetes MILES--Australia, the first Diabetes MILES initiative to be undertaken, was a national survey of adults living with ty...

Incidence of Type 1 Diabetes in Finland The incidence of type 1 diabetes (T1D), one of themost prevalent chronicdisease inchildren,has increasedworldwide.1The highest recorded incidence in children younger than 15 years was 64.2 per 100000person-years inFinland in 2005.2Weexamined the incidence rates between 2006 and 2011 in Finnish children younger than 15 years as well as the 32-year trend (1...