objectives: to investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. materials and methods: in this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (igf-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with a...

OBJECTIVES To compare the response between Chinese children with growth hormone deficiency (GHD) born either small for gestational age (SGA) or appropriate for gestational age (AGA) after 4 weeks of recombinant human growth hormone (r-hGH) therapy. METHODS This was a phase IV, open-label, multicenter, interventional study (NCT01187550). Prepubertal children with GHD received open-label treatm...

insulin-like growth factor-i (igf-1) is a peptide hormone which is similar in molecular structure to insulin and it is located on chromosome 5 in cattle. since the igf-1 plays an important role in the growth and development of multiple tissues, the purpose of current study was to identify the igf-1 gene polymorphism in sistani beef cattle. a total of 53 sistani beef cattle (one year) were rando...

The insulin-like growth factor (IGF) system, comprising insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), and their binding proteins (IGFBPs), is linked to cell growth, the development of cardiovascular disease, and several cancers. Little is known about its epidemiology. The authors studied relations of the IGF system to anthropometric and metabolic variables in thr...

In a case of acromegalic gigantism with hyperprolactinemia is reported, the basal serum growth hormone (GH) levels ranged from 1.2 to 1.9 ng/ml. Serum GH response to either insulin-induced hypoglycemia or GH-releasing hormone was blunted. Frequent blood sampling showed non-pulsatile GH secretion. Serum prolactin and insulin-like growth factor-I (IGF-I) levels were elevated. After unsuccessful s...

Several prospective observational studies have suggested that elevated circulating IGF-I levels are associated with an increased risk of cancer. These observations may provide a potential mechanism through which previously identified metabolic and anthropometric factors, such as obesity and elevated insulin and glucose levels, may operate. We therefore examined metabolic and anthropometric infl...

Insulin-like peptides are an ancient acquisition in phylogeny, suggesting a crucial biological role for these family of peptides. Indeed, a key function of these hormones in cell metabolism and growth has been firmly established. However, their significance in neuronal physiology is less characterized, although progress in recent years on the neuroactive properties of insulin and insulin-like g...

Introduction: Adenotonsillar hypertrophy (ATH) may present with growth retardation. Insulin-like growth factor 1 (IGF-1) mediates the anabolic effects of growth hormone (GH) on tissues. Most of the circulating IGF-1 molecules are bound to insulin-like growth factor-binding protein 3 (IGFBP-3). IGF-1 and IGFBP-3 serum levels reflect the levels of daily mean serum GH and are used as indices for e...

This report reviews the current knowledge on the biosynthesis, regulation and secretion of Growth Hormone (GH) and Insulin-like Growth factor-I (IGF-I). Variants of human GH, molecular size variants as well as charge variants, and the GH binding protein will be discussed, and the regulation of expression of the hGH gene is reviewed. IGF-I expression, regulation of the igf-I gene and secretion i...