In inverse planning for intensity-modulated radiation therapy (IMRT), the dose specification and related weighting factor of an objective function for involved organs is usually predefined by a single value and then iteratively optimized, subject to a set of dose-volume constraints. Because the actual dose distribution is essentially non-uniform and considerably affected by the geometric shape ...

Radiotherapy reduces the local relapse rate after pleuropneumonectomy of malignant pleural mesothelioma (MPM). The optimal treatment technique with photons remains undefined. Comparative planning for intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) was performed. Six MPM patients with significant postoperative intrathoracic air cavities were planned with IMRT ...

We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients trea...

A self-consistent monitor unit (MU) and isocenter point-dose calculation method has been developed that provides an independent verification of the MU for intensity modulated radiotherapy (IMRT) using the MIMiC (Nomos Corporation) multileaf collimator. The method takes into account two unique features of IMRT using the MIMiC: namely the gantry-dynamic arc delivery of intensity modulated photon ...

PURPOSE A method is presented to radiobiologically compare sequential (SEQ) and simultaneously integrated boost (SIB) breast radiotherapy. METHODS The method is based on identically prescribed biologically effective dose (iso-BED) which was achieved by different prescribed doses due to different fractionation schemes. It is performed by converting the calculated three-dimensional dose distrib...

BACKGROUND Radiotherapy technology is expanding rapidly. Volumetric Modulated Arc Therapy (VMAT) technologies such as RapidArc® (RA) may be a more efficient way of delivering intensity-modulated radiotherapy-like (IM) treatments. This study is an audit of the RA experience in an Australian department with a planning and economic comparison to IM. METHODS 30 consecutive prostate cancer patient...

BACKGROUND We investigated how varying the treatment margin and applying hippocampal sparing and proton therapy impact the risk of neurocognitive impairment in pediatric medulloblastoma patients compared with current standard 3D conformal radiotherapy. METHODS We included 17 pediatric medulloblastoma patients to represent the variability in tumor location relative to the hippocampal region. T...

Introduction: Due to the prevalence of skin problems in patients after radiotherapy, skin dose measuring is importance. Content: Skin in vivo dosimetry means measuring the patient's (or phantom) skin dose during radiotherapy. According to the ICRP 59, the dose at the depth of 0.07 mm is known as a skin dose. The most radiosensitive epidermis cells are located...