BACKGROUND Cutaneous leishmaniasis is a health problem in the world. Lesions should be treated on cosmetically or functionally important sites, such as the face and hands. Cantharidin is a terpenoid compound produced naturally by beetles of Meloidae and Oedemeridae families. OBJECTIVES The current study aimed to investigate the effect of cantharidin on Cutaneous Leishmaniasis (CL) lesions and...

CXCL8 (interlukin 8, IL-8) has a diverse spectrum of biological activities including T cell, neutrophil and basophil chemotactic properties. It is produced by a wide variety of cell types and plays a significant role in the initiation of the acute inflammatory response. During inflammation, CXCL8 attracts and activates leukocytes at the site of infection leading to leukocyte infiltration, which...

Paeoniflorin (PF) is a monoterpene glycoside and exhibits multiple effects, including anti-inflammation and immunoregulation. To date, the effect of PF on multiple sclerosis (MS) has not been investigated. In this study, we investigated the effect of PF in experimental autoimmune encephalomyelitis (EAE), an animal model for MS. After administered with PF, the onset and clinical symptoms of EAE ...

A 74-year-old woman was referred to our hospital because of a high-grade fever (38.6°C) and general fatigue. A physical examination showed hepatosplenomegaly and leg edema, but no sign of lymphadenopathy, skin lesions, or neurological abnormalities were detected. A laboratory study revealed a white blood cell count of 2,400/mm (not lymphocytosis) and elevated tumor markers for lymphoma (soluble...

About thirty years ago, the interlukin-6 (IL-6) which is the proinflammatory cytokine, was detected as the differentiation factor of B cell. IL-6 is able to induce maturation in B cells and as a result, B cells achieve the ability to produce antibodies. In addition to immune responses, the role of IL-6 has been known in neurogenesis (neurons and glial cells). The studies have showed that the ab...

Environmental exposures to a variety of pollutant elements especially fuel waste products may result in harmful impacts on several physiological systems. The inflammatory response and the hematological system are major affected aim study is reveal impact oil exposure parameters IL-6 workers detect which more as prognosticators for clinical disorders. This included three groups, 50 persons each....

Although acupuncture is widely used to manage pain, it remains highly controversial, largely due to the lack of a clear mechanism for its benefits. Here, we investigated the role of IL-33, a novel interleukin (IL)-1 family member, and its receptor ST2 in the analgesic effects of electroacupuncture (EA) on formalin-induced inflammatory pain. The results showed that 1) EA stimulation of ipsilater...

Epidermal growth factor receptor inhibitors(EGFRi) and Mitogen Activated Kinase inhibitors(MEKi) induce a folliculitis in 65-80% of patients, but it is unclear how they impact on the human hair follicle(HF). We have asked whether EGFRi/MEKi-induced associated with damage HFs immune privilege(IP) excessive HF secretion pro-inflammatory mediators. Scalp biopsies were taken from EGFRi-treated pati...

Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection. Methods: Ninety seven adult liver transplant patients who enrolled in this cross sec...