Being essentially cut off from the global scientific community, Ukrainian and Russian scientists have developed a new concept for the beneficial use of adaptation to artificial intermittent hypoxia in treating of many diseases. The basic mechanisms underlying intermittent hypoxic training were elaborated mainly in three areas: regulation of respiration, free radical production and mitochondrial...

BACKGROUND Despite increasing awareness of the National Asthma Education and Prevention Program guidelines, the relative contribution of symptom frequency or pulmonary function to the recommended asthma severity levels remains poorly understood. OBJECTIVE To determine whether adding lung function measurements to clinical history substantially changes the asthma severity classification, thereb...

BACKGROUND Treatment guidelines for asthma have been established based on asthma severity; there are limitations in the identification of underlying pathophysiology and prediction of prognosis in heterogeneous phenotypes of asthma. Although the complex interactions between environmental and genetic factors affect the development and progression of asthma, studies on asthma phenotypes considerin...

Allergy or asthma is triggered by inhaling allergens such as dust, mites, pet dander, pollens, and fungal molds. Samples were collected from various indoor environments including air conditioner filters, carpets, plant soil, living room air, pillow covers of residents in air-conditioned flats for screening the pollution their role allergies asthma. This study included 30 with school-aged childr...

Atopic Dermatitis is an intermittent severely pruritic eczematous dermatitis with scaly erythematous patches, vesiculation, crusting and fissuring. It a reaction pattern that presents variable clinical histological findings. affects at least 20% of school children 5-10 %of adults. constitutes atopy, condition altered reactivity to common mild environmental stimuli. Mainly the face flexures infa...

BACKGROUND Allergic rhinitis, especially when persistent (PER) and associated with asthma heavily impairs patients' quality of life (QoL). OBJECTIVE This study assessed the effect of mometasone furoate nasal spray (MFNS) on the QoL of patients with PER and asthma, using the Rhinasthma questionnaire (EUDRACT n. 2007-004683-45). METHODS Patients with moderate/severe PER and intermittent asthm...

The aim of our study was to determine how often asthma control is achieved in children and adolescents, and how asthma affects parents' and children's daily lives. Interviews, including the childhood asthma control test (C-ACT), were conducted with 1,284 parents of asthmatic children (aged 4-15 yrs), as well as with the children themselves (aged 8-15 yrs; n=943), in Canada, Greece, Hungary, the...

PURPOSE Steroids, inhaled and systemic, are used to treat airway inflammation in patients with asthma; however, steroids are recognized to cause a number of side effects, including osteoporosis. We evaluated the prevalence of osteopenia/osteoporosis in patients with moderate-severe asthma managed through the Edmonton Regional Severe Asthma Centre. METHODS We performed a retrospective chart re...

BACKGROUND Asthma management guidelines recommend a stepwise approach to instituting and adjusting anti-inflammatory controller therapy for children with asthma. The objective of this retrospective observational study was to describe prescribing patterns of asthma controller therapies for children in a primary care setting. METHODS Data from the UK General Practice Research Database were exam...

BACKGROUND Several Chlamydia pneumoniae (Cp) biomarkers have been associated with asthma but Cp-specific IgE (Cp IgE) has not been investigated extensively. Our objective was to investigate Cp IgE in community adult asthma patients. METHODS (1) Prevalence of Cp IgE (measured by immunoblotting) and Cp DNA (by polymerase chain reaction) in peripheral blood, and biomarker associations with asthm...