The chemosensitizing effects of cyclosporin A and verapamil on the cytotoxicity of adriamycin were investigated using MTT assay against two human retinoblastoma cell lines, Y79 and WERI-Rb-1. Y79 and WERI-Rb-1 were totally resistant to doses up to 5.0 micrograms/ml of verapamil. Cyclosporin A inhibited the survival of Y79 and WERI-Rb-1 dose-dependently, however, the maximum inhibition at the hi...

background: rhabdomyosarcoma is a rare malignant soft tissue sarcoma and the most common sarcoma of childhood. the purpose of this study was to investigate the distribution of age and sex of patients, pathological subtypes and to determine the role of staging and classification of rms on treatment outcome. materials and methods: this retrospective study included patients who diagnosed with rms ...

BUJO | VOL 2 | ISSUE 1 | SEPTEMBER 2014 Abstract Retinoblastoma often sparks interest because the underlying cancer gene mutation was the first to be identified and cloned. However, apart from its genetic intrigue, the condition illustrates the health disparities between more and less developed countries. We present a case of retinoblastoma in a 6 month old boy who presented with left eye leuko...

Early diagnosis of this disease is very crucial for the treatment becomes effective. In emerging medical field the analysis, diagnosis and treatment is necessary. In this review the importance is given to cancer in retinal part. Normally cancer is defined as when a cell grows out of control. In eye, due to blood vessels changes the cancer formed and it is termed as Retinoblastoma (RB). In child...

Background: Retinoblastoma is the most common embryonic tumor of retina of children. This tumor include 3-4% of all children malignancies during the age range 0-14 years. In this study, we reported the incidence, therapeutic protocols, and treatment outcome of children with RB in South west Iran. Methods: We retrospectively investigated the medical reports clinical and pathological features of...

background and objectives: retinoblastoma is the most common intraocular pediatric malignancy. angiogenic factor expression such as vegf (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. this study was performed to determine the role of angiogenesis in local invasion of retinoblastoma and its correlation with patients’ survival. mater...

The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is cause of Retinoblastoma. mutational inactivation both gene alleles brings this cancer. (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There growing interest in regulatory activities un...

purpose : to report two cases of retinoblastomas detected by “white pupillary reflex” end-gaze leukocoria via flash photographs reported by parents case reports : retinoblastoma, a malignant ocular tumor, can be manifested by leukocoria. herein, we report two cases, a 4-year-old boy and a 5-year-old girl, presented with the parents' chief complaint of end-gaze leukocoria. in further evalua...