The design of a supply chain has been considered by many practitioners and researchers recently. One model that is used to optimize distribution from a single facility (depot) to a set of retailers over a given planning horizon and considering stock management decisions is known as Inventory Routing Problem (IRP). This model tries to optimize the trade-off between inventory and transportation c...

Previously, we described a group of patients with hemocytopenia who did not conform to diagnostic criteria of known hematological and nonhematological diseases. Most patients responded well to adrenocortical hormone and/or high-dose intravenous immunoglobulin treatment, indicating that cytopenia might be mediated by autoantibodies. Autoantibodies were detected on the membrane of various bone ma...

Posttranscriptional regulation of genes of mammalian iron metabolism is mediated by the interaction of iron regulatory proteins (IRPs) with RNA stem-loop sequence elements known as iron-responsive elements (IREs). There are two identified IRPs, IRP1 and IRP2, each of which binds consensus IREs present in eukaryotic transcripts with equal affinity. Site-directed mutagenesis of IRP1 and IRP2 reve...

Anticancer therapy with doxorubicin (DOX) is limited by severe cardiotoxicity, presumably reflecting the intramyocardial formation of drug metabolites that alter cell constituents and functions. In a previous study, we showed that NADPH-supplemented cytosolic fractions from human myocardial samples can enzymatically reduce a carbonyl group in the side chain of DOX, yielding a secondary alcohol ...

BACKGROUND High-resolution manometry (HRM) has improved the accuracy of manometry in detecting achalasia and has helped distinguish between clinically relevant subtypes. This study investigated whether HRM metrics correlate with the achalasia symptoms and symptomatic outcomes of peroral esophageal myotomy (POEM). METHODS Of the 30 patients who were enrolled, 25 were treated with POEM, 12 of w...

nowadays, liveliness and rapid maintenance of the development process of the companies are dependent on the accurate and complete understanding of the merits of the financial activities. since these merits are relative concepts that are based on comparisons, lists of ranking and comparison of industries with each other act as useful signposts for managers, politicians, and investors. the point ...

A growing need to have ubiquitous connectivity has motivated our research to provide continuous connection between various wireless platforms such as cellular networks, WLANs and MANETs. In this paper we consider integration at the routing layer and propose two adaptable routing protocols (IRP-RD and IRP-PD) that exploit topology information stored at the fixed network components (cellular Base...

The aim of this paper is to demonstrate how integrated resource planning (IRP) oriented to the gas sector can be applied both in new networks and in mature networks, and to present the advantages of its application. One case study is described, in the western central region of Portugal, to illustrate the results of a pilot project on natural gas IRP implementation in a new network in the Europe...

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) have been measured by specific bioassays in pooled urine samples from prepubertal children, aged 2-6 yr, and from male adults. For children the mean urinary excretion of FSH was 2.2 U 2nd International Reference Preparation (2nd IRP) per liter and the mean urinary excretion of LH was 0.44 U 2nd IRP per liter. For adults the mean FS...

The integrated refinery-planning (IRP), an instrumental problem in the petroleum industry, is made of several subsystems, each of them involving a large number of decisions. Despite the complexity of the overall planning problem, this work presents a mathematical model of the refinery operations characterized by complete horizontal integration of subsystems from crude oil purchase through to pr...