1. By inoculating the scarified surface of both sides of the scrotum of rabbits with suspensions of Treponema pallidum, 100 per cent of infections were obtained on one side or the other. Infection through the unbroken skin could not be produced. 2. By gland transfers from animals with positive local inoculations, 87.5 per cent of takes were produced. 3. These two methods were used to test the p...

Anaerobic intestinal spirochetes of the genus Brachyspira are important enteric pathogens in animals, but they have not been extensively studied in humans. The presence of a layer of spirochetes attached by one cell end to the colorectal epithelium is known as intestinal spirochetosis (IS) (4). The clinical significance of this colonization is uncertain, but it has been linked to chronic diarrh...

BACKGROUND The anaerobic spirochete Brachyspira pilosicoli colonizes the large intestine of various species of birds and mammals, including humans. It causes "intestinal spirochetosis", a condition characterized by mild colitis, diarrhea and reduced growth. This study aimed to sequence and analyse the bacterial genome to investigate the genetic basis of its specialized ecology and virulence. ...

Colonic spirochetosis (CS) is a newly emerging infectious disease of humans and animals caused by the pathogenic spirochete Brachyspira (formerly Serpulina) pilosicoli. The purpose of this study was to characterize an antigen that was recognized by antibodies present in sera of challenge-exposed pigs. The gene encoding the antigen was identified by screening a plasmid library of human B. pilosi...

The field of gastroenterology includes many examples of organisms whose pathogenicity has been questioned in the past. Older members of the American Society for Clinical Pathology might remember the skepticism with which the original publications by Warren 1 and Marshall 2 detailing the description of Helicobacter pylori associated with chronic active gastritis were greeted. It was not until Ko...

Entomologist, Spirochetosis Transmission Enquiry Calcutta School of Tropical Mcdicinc. In October 1929, whilst on leave, I carried out a study of the anopheline fauna and malaria in Blmgalpur. The results of this investigation may be of some interest, as there is no previous detailed record of the anopheline fauna nor of the malaria of the place. Bhagalpur, the chief town and administrative hea...

we report the case of a 54-year-old iranian man who presented with melena from three months prior to admission. esophagogastroduodenoscopy and colonoscopy were normal. double balloon enteroscopy showed a pedunculated tumor located in the jejunum. he underwent laparotomy and resection of a 9.5 cm tumor from the distal jejunum. histopathologic evaluation confirmed the diagnosis of an inflammatory...