BACKGROUND We tested the hypothesis that higher levels of cardiorespiratory fitness are inversely associated with carotid artery intima media thickness in 746 (age 53 ± 7 yrs) men with type 2 diabetes. METHODS We measured common carotid intima media thickness and defined carotid atherosclerosis as a carotid intima media thickness > 1.0 mm. Cardiorespiratory fitness was directly measured by pe...

Diabetes mellitus is a risk factor for atherosclerosis/cardiovascular diseases. Atherosclerosis in diabetic patients has been linked to increased oxidative stress and intima-media thickness is used to detect its presence. Catalase is involved in hydrogen peroxide catabolism and is important in defense against oxidative stress, which contributes significantly to atherosclerotic processes. There ...

Although hyperhomocysteinemia is considered to be a key risk factor for atherosclerosis, especially in Western countries, its role in the Asian population is still controversial. In this study, we evaluated the determinants of homocysteine and carotid intima-media thickness, a clinical marker for the detection of atherosclerosis, in Japanese. In 289 Japanese adults (age 37-86 yrs), we screened ...

In the rabbit model of electrically induced intimal thickening, the adherence processes of different leukocyte subsets as well as the functional significance of leukocyte invasion in the initial migration of smooth muscle cells (SMCs) into the intima were studied by using monoclonal antibody (MAb) 60.3 (directed to the leukocyte adherence glycoprotein CD18), a known potent inhibitor of leukocyt...

introduction: sudden sensorineural hearing-loss (ssnhl) patients constitute approximately 2–3% of referrals to ear, nose and throat (ent) clinics. several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. in this research the atherosclerotic changes and their known risk factors are studied in ssnhl patients.   materials and ...

conclusions according to the results, there were no significant and meaningful differences comparing acs and csa groups of patients by ecds using three indicators of stenosis, plaque morphology and imt as indicators of atherosclerosis. results also display that patients with acs had more stenosis, more plaque and thicker intima–media, but these differences were not statistically significant (p ...

OBJECTIVE(S) Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. MATERIALS AND METHODS This study was conducted on 24 male C...

BACKGROUND AND PURPOSE Several measures of atherosclerosis predict the risk of stroke. However, a comparison between various measures of atherosclerosis is lacking, and limited information exists on the added value of individual measures of atherosclerosis to cardiovascular risk factors. We compared different measures of atherosclerosis in relation to stroke. METHODS The study was based on th...

AIMS Patients with type-2 diabetes mellitus have greater carotid intima media thickness and they are at risk for generalized atherosclerosis. This study aimed to compare the thickness of carotid artery intima media in type-2 diabetes mellitus patients with and without nonblood pressure component metabolic syndrome. SETTINGS AND DESIGN This was a comparative observational study conducted in th...

Thromboatherosclerotic and fibrous lesions were produced by endothelial damage with polyethylene catheters inserted into the aortas in rabbits on a normal diet. Two weeks after insertion of the catheters, the concentration of both free cholesterol and cholesteryl ester in the thromboatherosclerotic lesions was significantly greater than that in the adjacent normal intima. A further increase in ...