Introduction: The occurrence of subarachnoid hemorrhage (SAH) in traumatic brain injury (TBI) is 12% ~ 53% and related to poor outcome (1, 2). Early diagnosis of SAH and active intervention in removing hemorrhage from subarachnoid space is of great significance in the management of acuteTBI. Susceptibility weighted imaging (SWI) has been successfully applied in TBI and proved to be 6 times more...

BACKGROUND AND PURPOSE Seizures are a common complication of intracerebral hemorrhage (ICH). We developed a novel tool to quantify this risk in individual patients. METHODS Retrospective analysis of the observational Helsinki ICH Study (n=993; median follow-up, 2.7 years) and the Lille Prognosis of InTra-Cerebral Hemorrhage (n=325; 2.2 years) cohorts of consecutive ICH patients admitted betwe...

BACKGROUND AND PURPOSE Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans. METHODS We studied 5 consecutive patients with cerebral vasospasm who were treated with intra-arterial papaverine preserved with chlorobutanol and imaged with MRI fluid-a...

Aneurysmal subarachnoid hemorrhage- (aSAH-) associated vasospasm constitutes a clinicopathological entity, in which reversible vasculopathy, impaired autoregulatory function, and hypovolemia take place, and lead to the reduction of cerebral perfusion and finally ischemia. Cerebral vasospasm begins most often on the third day after the ictal event and reaches the maximum on the 5th-7th postictal...

BACKGROUND AND PURPOSE This study evaluated the safety and efficacy of aggressive mechanical clot disruption (AMCD) in acute stroke patients with persisting middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion after thrombolytic therapy. METHODS Retrospective case series were used from a prospectively collected stroke database on consecutive acute ischemic stroke patients t...

Objective: To discover and analyze the value of coagulant molecular marker in diagnosis of cerebral infarction after intracerebral hemorrhage. Methods: In this study, we selected a total of 42 patients with cerebral infarction after intracerebral hemorrhage as the experiment group; additionally, 42 patients with intracerebral hemorrhage were enrolled as the hemorrhage control group; besides, 42...

#### Notable in Neurology This Week This issue features an article that investigates whether MRI markers of cerebral small vessel disease differ according to self-reported race or ethnicity and any differences are associated with the risk intracerebral hemorrhage; another examines effect adrenomedullin on patients migraine. A featured Views & Reviews provides recommendations outcome measures s...

The incidence of cerebral amyloid angiopathy in a general population was evaluated in brains of 400 consecutive autopsies of residents of Hisayama, Japan (November 1971-October 1983). Six samples taken from frontal lobe, parietal lobe, temporal lobe, occipital lobe, hippocampus, and basal ganglia of the same side of each brain were stained with both hematoxylin and eosin and Congo red. The spec...

Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity. Two important areas are becoming the central research interest of subarachnoid hemorrhage: cerebral vasospasm and early brain injury. The authors have reviewed the major contributions in experimental subarachnoid hemorrhage documented in the medical literature in the past 5 years. Treatments interfering with...

Intracranial hemorrhage in hemophilia is an unusual manifestation of the disease. The cases hitherto reported have been those of subarachnoid rather than of intracerebral hemorrhage. Indeed, Gunther,2 writing in 1935, stated that no substantiated instance of cerebral hemorrhage in a hemophiliac had been detailed up to that date. Von Limbeck,5 however, is credited with the description of such a ...