BACKGROUND There was an increasing requirement for novel treatments of osteoarthritis (OA). The aim was to compare the efficacy of intraarticular Botulinum toxin type A (BoNT-A) and intraarticular hyaluronate plus rehabilitation exercise in patients with ankle OA. METHODS This was a prospective, randomized, assessor-blinded study with a 6-month follow-up period, conducted in the outpatient re...

Background: Primary gonarthrosis is a progressive disease that increases with age and leads to limitations in activities of daily living. Until surgery performed, nonsteroidal anti-inflammatory drugs, intraarticular injections, physical therapy methods are used.
 Purpose: This study aims compare the clinical outcomes intra- articular corticosteroid (CCS) hyaluro nic acid (HA) injections fo...

Efficacy Intra-articular corticosteroid injection is quick and simple to carry out and in RCTs it has a large effect size (ES) of 1.27 at 7 days postinjection for pain relief against placebo for knee OA [101]. It produces relatively rapid relief of severe pain within a few hours or days. Although this benefit is relatively short lasting, in RCTs (1–4 weeks), individual patients may derive benef...

effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously. The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT before injection, the greater the reduction of pain int...

Background Musculoskeletal ultrasound (US) is a rapidly evolving and powerful diagnostic modality, which is gaining popularity for the evaluation and management of joint damage and soft tissue diseases in children with JIA. Several studies have shown that clinical examination underestimates the presence of intra-articular fluid when compared to US. US guided aspiration allows direct observation...

In vivo effects of Yersinia enterocolitica 0:3 lipopolysaccharide (prepared from bacteria grown at 253C and 373C) were investigated after intraperitoneal (i.p.) and intraarticular (i.a.) injection in rats during 30 days of examination. The persistence of endotoxin in the peritoneal and the synovial cavities was demonstrated by the immunofluorescence technique. Peritoneal and synovial exudative ...