Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysm...

Lyme disease in the United States is caused predominantly by the spirochete Borrelia burgdorferi and affects multiple organ systems. Lyme Borreliosis infrequently involves the peripheral and central nervous system, and the term Neuroborreliosis is used for the latter case. The most common manifestations of Neuroborreliosis include cranial neuropathy and lymphocytic meningitis. It can also cause...

INTRODUCTION Induction of anaesthesia and its associated spikes in blood pressure can cause rupture of an aneurysm during intracranial surgery. Lidocaine can reportedly provide hemodynamic stability when applied before endotracheal intubation. Rapid injection of large doses of lidocaine can cause unconsciousness. CASE PRESENTATION Lidocaine was applied as the sole anaesthetic for induction an...

The pipeline™ embolization device (PED) is a braided, tubular, bimetallic endoluminal implant used for occlusion of intracranial aneurysms through flow disruption along the aneurysm neck. The authors report on two cases of giant internal carotid artery aneurysm treated with the PED. In the first case, an aneurysm measuring 26.4 mm was observed at the C3-C4 portion of the left internal carotid a...

PURPOSE Day-care management of unruptured intracranial aneurysms can shorten hospital stay, reduce medical cost and improve outcome. We present the process, outcome and duration of hospital stay for the management of unruptured intracranial aneurysms via a neurointervention clinic in a single center during the past four years. MATERIALS AND METHODS We analyzed 403 patients who were referred t...

Intracranial Aneurysms and Subarachnoid Hemorrhage. A Cooperative Study. Antifibrinolytic Therapy in Recent Onset Subarachnoid Hemorrhage • In this cooperative study among 13 institutions, 502 patients were treated with antifibrinolytic medication (epsilon-aminocaproic acid or tranexamic acid) within a 14-day period following rupture of an intracranial aneurysm. Mortality at the end of 14 days ...

BACKGROUND AND PURPOSE The molecular characteristics of intracranial aneurysms are still poorly documented. A rabbit elastase aneurysm model has been helpful in the evaluation of devices and strategies involved in endovascular treatment of aneurysms. The goal of this project was to document the molecular changes, assessed by gene chip microarrays, associated with the creation of aneurysms in th...

BACKGROUND Pure subdural hematoma (without subarachnoid, intraventricular, or intraparenchymal hemorrhage) due to a ruptured intracranial aneurysm is rare. Most reported cases involve an aneurysm along the internal carotid artery, posterior communicating artery, or middle cerebral artery. No reports have described an aneurysm along the transmastoid branches of the occipital artery. CASE DESCR...

Background: Cerebral aneurysm disease causes intracranial hemorrhage by rupturing, which can eventually, lead to organ failure or death. For this reason, it is important to anticipate the reasons for rupturing of a cerebral aneurysm from biomechanical point of view. Investigating this disease may even help the physicians to find treatments and predict the patient’s situation. This research was ...

559 Introduction 559 Clinical Material 562 Site of Aneurysm, Interval From SAH to Randomization 563 Treatment Followed According to Protocol 564 Age and Neurological Condition Related to Mortality 565 Age and Medical Condition Related to Mortality 569 Mortality With Respect to Neurological Condition and Interval From Lait Bleed to Surgery 572 Rebleeding Prior to Surgery 575 Cerebral Angiography...