Active immunization against Pseudomonas aeruginosa keratitis and systemic disease in mice was studied. In the first series of experiments, monovalent vaccine, administered orally or intraperitoneally, protected against subsequent corneal and intraperitoneal challenge with the homologous strain of P. aeruginosa; however, oral administration of vaccine elicited less protection than intraperitonea...

The existence of neural opioid-mediated networks that are specific for the modulation of nociception is well established. Parallel non-opioid pathways exist, but their underlying physiology is little known. We now report that oxytocin administered intraperitoneally to rats, and intraperitoneally or intracisternally to mice has an anti-nociceptive effect, which is related to the activation of de...

Imidazole, given intraperitoneally to rabbits, inhibited the prostaglandin E1-induced (PGE1) elevation of intraocular pressure. The maximum imidaz-le effect occurred at three to six hours after intraperitoneal infection. The prostaglandin E1-induced aqueous humor protein elevation was reduced markedly in the imidazole-pretreated rabbits. Intravenous administration of imidazole also was effectiv...

Candida albicans peritonitis developed in a 48-year-old man with a perforated gastric ulcer who subsequently was treated with intravenous amphotericin B. The drug penetrated well into the inflamed peritoneal cavity and eradicated the organism from the peritoneal fluid. Nevertheless, at post-mortem, Candida organisms were demonstrated in a gall-bladder empyema and within the gall-bladder wall. B...

The proliferation of Meth-A and AH6oCfibrosarcoma inoculated intraperitoneally was suppressed in all ntice given Eubacteriun lentu,tt (TYH-11) intraperitoneally. The proliferation of MH 134 hepatona and Ll2Io lytnphoitl ieukenria was also suppressed in sonte of the nice receivingthis strain. Artrongforns of solidtutnors, this bacterial strain curedsone micewith MHl34 hepanira The sunival tines ...

In October 1944, concentrated penicillin was prepared in my laboratory. It was tested on the standard strain of Staphylococcus aureus and found highly potent. Three white rats, each weighing about 100 grammes, were inoculated intraperitoneally with 0.5 c.cm. of fresh rat leprosy material. A subcutaneous injection with 0.5 c.cm. of the material was also given in the groin at the same time. From ...

Polyethylene glycols (PEGs) are commonly employed as excipients in preclinical studies and in vitro experiments to dissolve poorly hydrosoluble drugs. Their use is generally considered safe in both animals and humans; however, limited data is available concerning the safety of PEGs when administered parenterally. The results of our investigation demonstrate that PEG-400 can have an irritant eff...

We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log(10) CFU per gram of vegetation after 3 days of treatment. The median log(1...

Background: Diospyros malabarica (Desr.) Kostel, a small to medium-sized tree in the Ebenaceae family, is known as “Deshi Gab” Bangladesh. Fever, diabetes, snake bite, diarrhea, biliousness, and ulcer ailments are all treated with herb. This study’s goal was examine mouse models antinociceptive properties of methanol extract leaves (MEDM). Methods: For purpose determining activity mice, five di...