BACKGROUND We evaluated the efficacy and safety of ketorolac (Toradol). METHODS In this prospective trial, 88 women in confirmed preterm labor at < or =32 weeks' gestation were randomized to receive magnesium sulfate given as an initial 6 g intravenous bolus followed by continuous infusion therapy (2 to 6 g/hr) or intramuscularly administered ketorolac (60 mg loading dose) followed by 30 mg e...

BACKGROUND Neonatal nonoliguric hyperkalemia (NOHK) is a metabolic abnormality that occurs in extremely premature neonates at approximately 24 h after birth and is mainly due to the immature functioning of the sodium (Na+)/potassium (K+) pump. Magnesium sulfate is frequently used in obstetrical practice to prevent preterm labor and to treat preeclampsia; this medication can also cause hypermagn...

based on a number of studies, magnesium sulfate (mgso4) given after a diffuse axonal injury has gained attention as a useful neuroprotective agent .the present study was conducted to examine if magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. adult patients admitted within 1 hour of a closed traumatic brain injury (tbi) with a severe diffu...

The purpose of our study was to investigate the effect of hypermagnesemia on spinal metabolic rate. The 2-[14C]deoxyglucose technique was used to measure regional glucose utilization in the lumbar spinal cord of paralyzed, mechanically ventilated rats receiving 70% nitrous oxide and an intravenous infusion of either saline (n = 5) or magnesium sulfate (n = 5). Plasma magnesium concentrations we...

The study was conducted to assess &amp; compare the effect of pretreatment with intravenous Dexmedetomidine and Magnesium sulphate on characteristics SAB hyperbaric bupivacaine. 80 ASA grade I II patients (age: 18-60 years) scheduled for infraumblical surgery under spinal anesthesia were included randomly divided into group-D (dexmedetomidine 1μ gm/kg) group-M (magnesium sulfate 50 mg/kg). give...

BACKGROUND Neuropathic pain is difficult to treat, and the efficacy of recommended drugs remains limited. N-methyl-D-aspartate receptors are implicated, and antagonists are a pharmacological option. Ketamine is widely used in French pain clinics, but without consensus or recommendations. Furthermore, the association of ketamine with magnesium has been poorly studied. The aim of the present stud...

OBJECTIVE To investigate the effects of two tocolytics, nifedipine and magnesium sulfate, on Doppler indices in maternal and fetal vessels. MATERIALS AND METHODS We recruited 100 pregnant women with preterm birth between 24-36 gestational weeks who were admitted to our tertiary center over a two-year period. Patients were allocated to nifedipine (n=49) and magnesium sulfate (n=51) groups and ...

though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

The aim of our study was to analyze the long-term survival and cardiac function in 194 consecutive, thrombolysis-ineligible acute myocardial infarction (AMI) patients receiving 48-hour intravenous magnesium sulfate (22 g) - 96 patients, compared with placebo - 98 patients. After a mean 4.8-year follow-up, all-cause mortality and cardiac mortality were significantly lower in the magnesium compar...

conclusions this study showed that the addition of intrathecal magnesium sulfate to bupivacaine is not desirable in patients undergoing cesarean section due to the delay in the onset of sensory blockade and the lack of significant effects of magnesium on post-operative pain. results the onset of sensory blockade was delayed in case group compared with control group, and this was statistically s...