27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Pulmonary aspergillosis (PA) in non-immunocompromised hosts, although rare, is increasingly recognized. The diagnosis of PA is difficult, since recovery of Aspergillus from respiratory samples cannot differentiate colonization from invasion. We assessed the role of BAL galactomannan (GM) in diagnosing PA in 73 non-immunocompromised pat...

27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 Pulmonary aspergillosis (PA) in non-immunocompromised hosts, although rare, is increasingly recognized. The diagnosis of PA is difficult, since recovery of Aspergillus from respiratory samples cannot differentiate colonization from invasion. We assessed the role of BAL galactomannan (GM) in diagnosing PA in 73 non-immunocompromised pat...

Background: Invasive pulmonary aspergillosis (IPA) is an infection often occurring in neutropenic patients and has high mortality rates. In recent years, it has been reported that the incidence of IPA has also increased in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study is to investigate the clinical and demographic characteristics and treatment responses o...

The identification of the causative organism in invasive pulmonary aspergillosis (IPA) is recommended. We investigated whether a mycologic diagnostic strategy could be optimized based on patient characteristics. Fifty-five patients were enrolled in a prospective study. The presence of Aspergillus in respiratory samples occurred more frequently in non-acute leukemia (AL) patients than in AL pati...

Background: Invasive pulmonary aspergillosis (IPA) is an infection that primarily affects immunocompromised hosts, including hematological patients and stem-cell transplant recipients. The diagnosis of IPA remains challenging, making desirable the availability of new specific biomarkers. High-throughput methods now allow us to interrogate the immune system for multiple markers of inflammation w...

Invasive pulmonary aspergillosis (IPA) is a life-threatening disease of immunocompromised patients that requires aggressive therapy. Detection of the disease and monitoring of the therapeutic response during IPA are complex, and current molecular diagnostics are not suitably robust. Here, we explored proteomic profiles of bronchoalveolar lavage fluid (BALF) specimens from a persistently neutrop...

BACKGROUND Two serologic assays, Aspergillus latex agglutination testing (LA) and plasma (1-->3)-beta-D-glucan (BDG) measurement, are used when invasive pulmonary aspergillosis (IPA) is suspected. Despite the high specificity of these assays, false-positive results are frequent for neutropenic patients. This study was conducted to evaluate the efficacy of LA and BDG and to investigate the cause...

The aim of this study was to investigate the value of serum Galactomannan (GM) detection for the early diagnosis of Invasive Pulmonary Aspergillosis (IPA) in children as a reference for clinical diagnosis and treatment. A total of 80 high-risk children with IPA were selected (including three confirmed cases, 20 clinically diagnosed cases, 25 suspected cases, and 32 non-IPA patients) for the det...

Invasive pulmonary aspergillosis (IPA) is frequent and often fatal in immunosuppressed patients. Timely diagnosis of IPA improves survival but is difficult to make. We examined the analytical and clinical validity of galactomannan (GM) testing of bronchoalveolar lavage (BAL) fluid in diagnosing IPA in a mixed population by retrospectively reviewing records of 251 consecutive at-risk patients fo...