One factor that is critical to the potential effectiveness of radioimmunotherapy is the design of radiometal-chelated antibodies that will be stable in vivo. Stability in vivo depends on the condition that both the chelate linkage and radiolabeling procedures not alter antibody specificity and biodistribution. In addition, synthesis and selection of the chelating agent is critical for each radi...

OBJECTIVE The aim of the present study was to evaluate the outcome of radioiodine treatment in thyrotoxicosis in childhood and adolescence. METHODS This was a retrospective study of 27 patients (ages 7.2- 19.8 years) with a diagnosis of thyrotoxicosis who received iodine-131 (I-131) treatment from January 2007 to December 2011 in the Nuclear Medicine Division, Department of Radiology, Faculty...

Targeted radioimmunotherapy in non-Hodgkin's B-cell lymphoma (NHL) offers an efficacious therapy and minimal toxicity compared to conventional chemotherapy. Iodine 131 tositumomab ((131)I-TST) is a murine monoclonal antibody against the CD20 cell surface protein and is directly covalently conjugated to (131)I, a radioactive beta and gamma emitter. While initially approved for use in relapsed, r...

Here we define two cases with a diffuse soft tissue uptake of I-131 in neck and mediastinum on post ablation scan. A diffuse uptake of I-131 in the soft tissue is very rare. In this case report we review the literature and discuss the mechanism of the uptake.

The activity per unit mass of an iodine-131 solution was absolutely standardized by both the 4πβ-γ coincidence method and the 4πγ counting technique. The calibrated solution was used to prepare point sources after a preliminary deposit of AgNO3 to prevent the loss of volatile iodine. Relative and absolute photon emission intensities of 15 sgamma-rays and those of the two K X-rays of xenon were ...

BACKGROUND Iodine-131 ((131)I) is a well-established method for the treatment of hyperthyroidism. Following such therapy, patients may experience symptoms relating to early or delayed side effects that can be prevented or minimized if necessary measures are taken. We have noticed an unusual side effect of (131)I therapy in the form of a skin eruption (iododerma) and aimed at assessing the frequ...

A 73-y-old patient who had thyroid carcinoma had a post-treatment, whole-body 131I scan. The scan demonstrated an artifact caused by a bracelet contaminated with radioactive perspiration. This finding resulted in an artifact on the scan and had potential radiation safety implications.

thyroid scintigraphy has been helpful in detecting and evaluation of thyroid nodules. sodium pertechnetate tc-99m is the most commonly used radionuclide for thyroid imaging because of its general availability, favorable dosimetric characteristics and low cost. but, there are reports of occasional disparity in isotope uptake in lesions compared with radioiodide. in order to determine percentage ...

OBJECTIVES Median urinary iodine concentration (UIC) is the recommended method to evaluate iodine status in pregnancy, but several factors may challenge the interpretation of the results. We evaluated UIC in pregnant women according to (1) sampling in the hospital versus at home, (2) time of the most recent iodine supplement intake prior to sampling, and (3) members of their household. STUDY ...

I131 is a famous radio-iodine isotope in use for diagnosis and treatment of hyper functioning and cancerous thyroid gland. It is a nuclear reactor product; however nuclear reactor may be unavailable in some areas. Replacement by I-124 may be possible, another iodine isotope producible by cyclotron; a system more available than reactor. Here absorbed fraction of Gamma and Beta rays of...