PURPOSE Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST). This phase I study investigated the safety and maximum tolerated dose (MTD) of retaspimycin hydrochloride (IPI-504), a novel potent and selective HSP...

Achieving secure communication between an Implantable Medical Device (IMD) and a gateway or programming device outside the body has showed its criticality in recent reports of vulnerabilities cardiac devices, insulin pumps neural implants, amongst others. The use asymmetric cryptography is typically not practical solution for IMDs due to scarce computational power resources. Symmetric key prefe...

The International Prognostic Index (IPI; age, the disease stage according to the Ann Arbor system, serum lactate dehydrogenase (LDH), Eastern Cooperative Oncology Group (ECOG) performance status (PS) and the presence of extranodal involvement (ENI)) has been the traditionally utilized prognostic tool for diffuse large B-cell lymphoma (DLBCL) treated with cyclophosphamide, doxorubicin, vincristi...

Our aim was to study the effect of estradiol (E2) on pulsatile GnRH secretion in vitro in relation to sex and development. When hypothalamic explants obtained from 5- and 15-d-old female rats were exposed to E2 (10(-7) m), a reduction of GnRH interpulse interval (IPI) occurred but not at 25 and 50 d of age. This effect was prevented by the estrogen receptor antagonist ICI 182.780 and the AMPA/k...

Results 14 patients were female. The median age was 63 years (30-90). 13 had localized disease. The tumor had an axial location in 20 patients (80%). 6 patients presented with a pathologic fracture. The histological type was NonHodgkin Lymphoma B in all patients. There were 18 high grade lymphomas. According to the IPI, 8 cases (32%) were classified as low risk, 11 cases (44%) as intermediate r...

OBJECTIVE To determine whether subsequent births after short and long interpregnancy intervals (IPIs) are associated with risk of autism spectrum disorder (ASD). METHOD We assessed the association between IPI and ASD risk in a cohort of 45 261 children born at Kaiser Permanente Northern California (KPNC) between 2000 and 2009. Children with ASD were identified from International Classificatio...

BACKGROUND We conducted a comparative study in worksites to assess the impact of sexual health promoting interventions on contraceptive use among female rural-to-urban migrants. STUDY DESIGN In Qingdao ten manufacturing worksites were randomly allocated to a standard package of interventions (SPI) and an intensive package of interventions (IPI). The interventions ran from July 2008 to January...

BACKGROUND/AIM Follicular lymphoma (FL) is a B-cell tumor usually with indolent clinical course, yet in some cases the course of the disease can be very aggressive. The aim of the research was to determine distribution of patients into prognostic groups based on the International Prognostic Index (IPI) and Folicular Lymphoma International Prognostic Index (FLIPI) criteria, as well as to determi...