Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential to life, yet this same chemistry mediates deleterious reactions with oxygen tha...

Ancylostoma duodenale and Necator americanus are extremely common species of soil-transmitted helminth which flourish where poverty and malnutrition prevail. Hookworms contribute significantly to iron-deficiency anaemia, which remains one of the world's major nutritional problems, through the feeding activities of intestinal stages leading to chronic blood loss into the gut. In this article, a ...

BACKGROUND Iron is vital for almost all living organisms by participating in a wide range of metabolic processes. However, iron concentration in body tissues must be tightly regulated since excessive iron may lead to microbial infections or cause tissue damage. Disorders of iron metabolism are among the most common human diseases and cover several conditions with varied clinical manifestations....

The endeavours of physicians taxed with the problem of iron deficiency over the last 100 years have successfully eliminated this as an issue of hematological interest. Iron overload, although by no means a new problem, has drawn much more attention over the last few decades. The development of reliable indicative tests of iron status since the early 1970s has sparked a revolution in our underst...

Aim of the study to determine iron metabolism markers in with benign and malignant processes of ovaries and uterus. Study object: blood serum of 50 patients with benign and malignant processes of ovaries and uterus. Methods: clinical, morphological, immunoenzyme, immunochemiluminescent, immunoturbidimetric. Results: in the group of patients with malignant processes there were more patients with...

β-thalassemia is a disease characterized by anemia and is associated with ineffective erythropoiesis and iron dysregulation resulting in iron overload. The peptide hormone hepcidin regulates iron metabolism, and insufficient hepcidin synthesis is responsible for iron overload in minimally transfused patients with this disease. Understanding the crosstalk between erythropoiesis and iron metaboli...

Abilities of bacterial pathogens to adapt to the iron limitation present in hosts is critical to their virulence. Bacterial pathogens have evolved diverse strategies to coordinately regulate iron metabolism and virulence associated functions to maintain iron homeostasis in response to changing iron availability in the environment. In many bacteria the ferric uptake regulator (Fur) functions as ...