Iron is an essential micronutrient for all eukaryotic organisms. However, the low solubility of ferric iron has tremendously increased the prevalence of iron deficiency anemia, especially in women and children, with dramatic consequences. Baker's yeast Saccharomyces cerevisiae is used as a model eukaryotic organism, a fermentative microorganism, and a feed supplement. In this report, we explore...

Despite the mammalian host actively sequestering iron to limit pathogenicity, heme (or hemin when oxidized) and hemoproteins serve as important sources of iron for many bloodborne pathogens. The HmuRSTUV hemin uptake system allows Yersinia species to uptake and utilize hemin and hemoproteins as iron sources. HmuR is a TonB-dependent outer membrane receptor for hemin and hemoproteins. HmuTUV com...

We present evidence for a skewed distribution of UV Fe ii emission in quasars within candidate overdense regions spanning spatial scales of ∼ 50 Mpc at 1.11 < z < 1.67, compared to quasars in field environments at comparable redshifts. The overdense regions have an excess of high equivalent width sources (W2400 > 42 Å), and a dearth of low equivalent width sources. There are various possible ex...

Background: Iron deficiency anemia (IDA) is the most common cause of anemia worldwide. It is widely accepted that chronic occult blood loss from the gastrointestinal tract is a major cause of IDA. This study aimed to evaluate small intestinal lesions in patients with unexplained iron deficiency anemia, with or without fecal occult blood by enteroscopy and to elucidate the pathologic nature of s...

To survive and multiply within their hosts, pathogens must possess efficient iron-scavenging mechanisms. In the present study, we investigate the capacity of Prevotella nigrescens and Prevotella intermedia to use various sources of iron for growth and characterize the transferrin-binding activity of P. nigrescens. Iron-saturated human transferrin and lactoferrin, but not ferric chloride and the...