Here we show a novel mechanism by which FLICE-like inhibitory protein (c-FLIP) regulates apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and one of its receptors, DR5. c-FLIP is a critical regulator of the TNF family of cytokine receptor signaling. c-FLIP has been postulated to prevent formation of the competent death-inducing signaling complex (DISC) ...

A fully-static flip-flop structure is proposed and compared to both the conventional CMOS flip-flop and the Cascode Voltage Switch Logic (CVSL) static flip-flop proposed by Yuan and Svensson [I], in terms of speed, power consumption and silicon area. Then an add-and-delay circuit is implemented using all three flip-flop structures to demonstrate the performance of the proposed flip-flop. The ad...

Efficient power management in wireless sensor network is a critical issue as the sensor nodes are low powered devices. In a sensor node, flip flop consumes large amount of power as they make maximum number of internal transitions. Reduction in the power consumed by flip-flops shows a deep impact on the total power consumed. Hence, designing low power flip flop cells are highly important for enh...

There is a wide selection of flip-flops in the literature. Many contemporary microprocessors selectively use master-slave and pulsed-triggered flip-flops. Transmission gated flip-flop, are made up of two stages, one master and one slave Alternatively, pulse-triggered flip-flops reduce the two stages into one stage and are characterized by the soft edge property. The concepts discussed in the re...

We study flip graphs of (pseudo-)triangulations whose maximum vertex degree is bounded by a constant k. In particular, we consider (pseudo-)triangulations of sets of n points in convex position in the plane and prove that their flip graph is connected if and only if k > 6; the diameter of the flip graph is O(n). We also show that for general point sets flip graphs of minimum pseudo-triangulatio...

Pulse-triggered flip-flops are mainly used to improve speed of operation (pipeline speed), though flip-flop robustness and system timing closure are challenging in a wide range of supply voltages. Usually pulse-triggered flip-flops have specific structures and transistor sizes to optimize the system performance. The transistor size, topology, and threshold voltage of the flip-flop make the timi...

Background: Mycosis fungoides (MF) is the commonest variant of primary cutaneous T cell lymphoma with several clinicopathologic variants. Defective apoptotic mechanism may be important in the pathogenesis and progression of MF. c-FLIP protein is an important anti-apoptotic marker and chemotherapeutic resistant factor. This study aimed to evaluate the c-FLIP expression in MF and its role in the ...