Of patients who undergo cardiopulmonary bypass (CPB), a procedure essential to most cardiac operations, '1% to 2% develop a syndrome of pulmonary dysfunction called the postpump syndrome, which is analogous to the adult respiratory distress syndrome (ARDS) that develops as a complication of trauma, sepsis, inhalation injury, aspiration pneumonia, pancreatitis, and other disease states.1,2 This ...

For us neonatologists, research about necrotizing enterocolitis always incites great curiosity, because our understanding of its physiopathology is largely speculative, and this illness haunts the neonatal intensive care unit. Nowadays, as viability increases, the prevalence of necrotizing enterocolitis is becoming more important because we are taking care of more immature and lower birth-weigh...

Ischemia-reperfusion injury is a common feature of ischemic stroke, which occurs when blood supply is restored after a period of ischemia. Reperfusion can be achieved either by thrombolysis using thrombolytic reagents such as tissue plasminogen activator (tPA), or through mechanical removal of thrombi. Spontaneous reperfusion also occurs after ischemic stroke. However, despite the beneficial ef...

Background: Devastating extremity injuries are prevalent but most often survivable on the modern battlefield. The complexity of these injuries requires advanced methods of reconstruction. This study is designed to validate the feasibility of gracilis myocutaneous flap transplantation via microvascular free tissue transfer in a porcine model. This model will facilitate study of autotransplant ph...

Recent data of ours demonstrate that naringenin, a flavanone derivative typical of the Citrus genus, possesses cardioprotective effects in rat hearts submitted to ischemia/reperfusion injury [Testai et al., 2013a]. These effects are due, at least in part, to a mitochondria-targeted action, since naringenin activates a mitochondrial calcium-dependent potassium channel (mitoBKCa), localized in th...

the viewpoint of not only animal welfare but also the reliability of pharmacological studies. The type of anesthetics used may vary depending on the type of experiment required or the study design. Some anesthetics have cardioor renoprotective effects, which may be relevant in designing ischemiareperfusion protocols. Several studies have examined the influence of commonly used anesthetics on th...

Molnar, M. 2015. Hyperglycemia in Experimental Cerebral Ischemia. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1089. 86 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9216-8. Cerebral ischemia is a life-threatening condition associated with a substantial morbidity and mortality. Hyperglycemia, a common coexisting phenomenon in both stroke a...

Early reperfusion of totally occluded coronary arteries with thrombolysis and/or percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) reduces infarct size, cardiac mortality, and in-hospital events.1,2 Prompt reperfusion of epicardial blood flow reduces infarct size and mortality rates, in-hospital events, and reinfarction. Furthermore, successful reperfusion greatly a...

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...