Ischemic cardiomyopathy and resultant heart failure (HF) are significant causes of morbidity mortality worldwide. Mainstay therapeutic options limited to the blockade neurohormonal stress pathways. An unmet need in HF therapy is development targeted myocardium-specific therapies. Cardiac bridging integrator 1 (cBIN1), a membrane scaffolding protein transverse-tubule microdomains, organizes calc...

Chronic hepatitis C can be associated with extrahepatic manifestations; thus, we explored the association of this viral infection with dilated cardiomyopathy in a group of sixty-three patients with a cardiac ejection fraction of less than 40% determined by an echocardiogram in a prospective study. Two of the forty-one patients with non-ischemic cardiomyopathy (4.8%) had serum antibodies to the ...

A 58-year-old man had been diagnosed with non-obstructive hypertrophic cardiomyopathy (HCMP) according to echocardiography findings 16 years ago. Echocardiography showed ischemic cardiomyopathy (CMP)-like features with decreased systolic function but a non-dilated chamber. Coronary angiography was performed but showed a normal coronary artery. Cardiac magnetic resonance imaging (MRI) revealed m...

background: cardiac resynchronization therapy (crt) is an effective treatment for patients with moderate to severe heart failure. however, 20-30% of patients remain non-responders to crt. we sought to identify which patients benefit the most from crt in regard to the etiology of heart failure. methods: eighty-three consecutive patients (62 men) who had a biventricular pacemaker inserted at tehr...

Syncope is a frequent symptom, but when it occurs in the presence of organic heart disease and there is no obvious explanation, it carries with it a high incidence of subsequent sudden death. Several investigators have demonstrated that unexplained syncope in patients with dilated cardiomyopathy, particularly with clinical congestive heart failure (CHF), is a predictor of overall mortality and ...