Both the incidence of acute ST-segment–elevation myocardial infarction (STEMI) and the mortality from STEMI have decreased over the last 3 decades. However, despite the success of reperfusion therapy by primary percutaneous coronary intervention (PCI) or thrombolysis, STEMI is still of significant concern. Although door-to-balloon time for primary PCI has declined, mortality has not, possibly b...

We present the case of a 65-year-old man with type 2 diabetes mellitus, arterial hypertension, hypercholesterolemia, salicylate allergy and diagnosed ischemic heart disease since 2000. The patient, despite intensive pharmacotherapy according to European Society Cardiology guidelines insertion as many 11 stents into coronary arteries, had persistent recurrent acute syndromes, including 4 myocard...

BACKGROUND The distribution of cerebral ischemic infarction and stenosis in ischemic stroke may vary with age-group, race and gender. This study was conducted to understand the risk factors and characteristics of cerebral infarction and stenosis of vessels in young Chinese patients with ischemic stroke. METHODS This was a retrospective study, from January 2007 to July 2012, of 123 patients ≤5...

#### Notable in Neurology This Week This issue features an article that evaluates the association between silent myocardial infarction and subsequent ischemic stroke, a review discusses diagnosis, pathophysiology, management of transient focal neurologic episodes related to cerebral amyloid angiopathy. A featured Special Article presents 2020 update American Academy Neurology's Parkinson disea...

First described by Thomas Willis in 1679 and defined in the 1950s, transient ischemic attack is universally agreed to be an episode of focal neurologic deficit in a vascular distribution, sudden in onset and resolving without residual deficit in less than or equal to 24 hours. Transient ischemic attack is diagnosed by characteristic history and absence of residua on neurologic examination. Afte...

Inherited disorders of hemostasis are natural models for investigating mechanisms of thrombosis and development of antithrombotic therapy. Because mice with total factor XI deficiency are protected against ischemic stroke and do not manifest excessive bleeding, we investigated the incidence of ischemic stroke in patients with severe inherited factor XI deficiency. Incidence of ischemic stroke i...

Acute myocardial infarction is a frequent and disabling disease. Ischemic postconditioning, consisting of repeated brief cycles of ischemia-reperfusion performed immediately after reperfusion following a prolonged ischemic insult, dramatically reduces infarct size in experimental models. A recent clinical study demonstrated that repeated brief episodes of inflation-deflation of the angioplasty ...

Objective: To study the risk factors of cerebral infarction in stroke patients. Methodology: It is a descriptive hospital based study conducted at the Department of Medicine, Naseer Teaching Hospital, Peshawar from January 2005 to December 2005. One hundred patients of stroke with cerebral infarction confirmed on C.T. scan brain and more than twenty years of age were included. Risk factors for ...

It is reasonable to speculate that migrainous infarction may develop in different territories of cerebral arteries. However, this condition was rarely reported before. Here we described two patients (one woman, 29 year-old; one man, 47 year-old) with a history of migraine with aura, had ischemic strokes during the migraine attack. The ischemic stroke of the female patient involved the territori...

BACKGROUND AND PURPOSE We tested the hypothesis that observationally and genetically elevated YKL-40 is associated with elevated lipids and lipoproteins and with increased risk of ischemic vascular disease. METHODS We conducted cohort and Mendelian randomization studies in 96 110 individuals from the Danish general population, with measured plasma levels of YKL-40 (n=21 647), plasma lipids an...