UNLABELLED Ischemic preconditioning (IPC) is a robust neuroprotective phenomenon whereby brief ischemic exposure confers tolerance to a subsequent ischemic challenge. IPC has not been studied selectively in CNS white matter (WM), although stroke frequently involves WM. We determined whether IPC is present in WM and, if so, its mechanism. We delivered a brief in vivo preconditioning ischemic ins...

Background and Purpose: The relation between the redistribution phenomenon and regional cerebral blood flow and its clinical significance were investigated in stroke patients. Methods: Single-photon emission computed tomography studies using N-isopropyl-p-[1u31]iodoamphetamine were performed on 16 patients (26 to 77 years old) with chronic infarction and 10 age-matched normal control subjects. ...

Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. 83. B.R. Ransom, S.B.T. Perceptor pharmacology of excitotoxic injury in mouse optic nerve. in Program No. 100.13. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. 2005. 84. Ransom, B.R. and A.M. Brown. Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back. Neu...

Rundown of ionic gradients is a central feature of white matter anoxic injury; however, little is known about the contribution of anions such as Cl-. We used the in vitro rat optic nerve to study the role of aberrant Cl- transport in anoxia/ischemia. After 30 min of anoxia (NaN3, 2 mm), axonal membrane potential (V(m)) decreased to 42 +/- 11% of control and to 73 +/- 11% in the presence of tetr...

Models of premature brain injury have largely focused on the white matter injury thought to underlie periventricular leukomalacia (PVL). However, with increased survival of very low birth weight infants, injury patterns involving grey matter are now recognized. We aimed to determine how grey matter lesions relate to hypoxic-ischemic- (HI) mediated white matter injury by modifying our rat model ...

The role of white matter changes in aging and Alzheimer's disease The overall goal of my research is to elucidate the role of white matter pathology in the development of age-related cognitive deficits. Currently, our studies have shown two significant changes in white matter pathology with aging malfunctioning of oligodendrocytes and demyelination of axons. Further, cholesterol trafficking is ...

BACKGROUND AND PURPOSE Hypoxia is commonly known to target neuronal cell bodies. Although myelin is a non-infrequent target, posthypoxic demyelination is a rarely described entity. We describe the case of a man who developed neurogenic bladder following a motor vehicle accident. CASE REPORT Following a severe motor-vehicle accident involving massive blood loss, a 46-year-old man developed uri...

Recurrent transient ischemic attacks, migraine and dementia represent the principal symptoms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL). During the course of the disease, about 10% of patients may experience epileptic seizures, mainly related to the presence of an ischemic stroke. We present a 30-year-old woman with new-onset focal ep...