نتایج جستجو برای: isocoumarin
تعداد نتایج: 145 فیلتر نتایج به سال:
with 300 ml of ^2-hexane. The water-alcohol fraction was extracted twice with 300ml of CH2C12and the active CH2C12 extracts concentrated to yield 600mg. The extract was chromatographed on a silica gel column using hexane EtOAcas eluting solvent. Fractions with antitumor activity (280 mg) were eluted with w-hexane EtOAc 75 : 25. Column chromatography on silica gel was repeated and the activity (...
We examined the effects of a new antiangiogenic isocoumarin, NM-3, as a radiation modifier in vitro and in vivo. The present studies demonstrate that NM-3 is cytotoxic to human umbilical vein endothelial cells (HUVECs) but not to Lewis lung carcinoma (LLC) cells nor Seg-1, esophageal adenocarcinoma cells, in clonogenic survival assays. When HUVEC cultures are treated with NM-3 combined with ion...
Isocoumarins are a large and structurally diverse class of bioactive natural products with widespread occurance in living organisms [1], and considerable work has been published over decades about their chemistry [2] and biology [3]. A considerable number of natural and synthetic isocoumarins showed significant cytotoxic and antitumor activity. Among those are dihydroisocoumarins like AI-77-B (...
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