نتایج جستجو برای: isoindoline

تعداد نتایج: 246  

2010
K. Shiva Prasad L. Shiva Kumar Melvin Prasad Hosakere D. Revanasiddappa

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L(1)), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L(2)) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-D...

2009
Jiang-Sheng Li Jim Simpson Xun Li

The mol-ecule of the title compound [systematic name: 2-(4-tert-butyl-benz-yl)isoindoline-1,3-dione], C(19)H(19)NO(2), is V-shaped with a dihedral angle of 74.15 (7)° between the mean planes of the phthalimide unit and the benzene ring. The methyl groups of the tert-butyl substituent are disordered over two sets of positions, with an occupancy ratio of 0.700 (4):0.300 (4). In the crystal, inter...

2011
Moazzam H. Bhatti Uzma Yunus Sohail Saeed Syed Raza Shah Wing-Tak Wong

In the title complex, [Ca(C(10)H(6)NO(4))(2)(H(2)O)(2)](n), the Ca(II) atom lies on a twofold rotation axis and adopts a dodeca-hedral geometry. The Ca(II) atom is octa-coordinated by two O atoms from two water mol-ecules and six O atoms from four acetate ligands. Each acetate acts as a tridentate ligand bridging two Ca(II) atoms, resulting in a chain running along the c axis. O-H⋯O and C-H⋯O h...

Journal: :Free radical research 2015
A P Jagtap I Krstic N C Kunjir R Hänsel T F Prisner S Th Sigurdsson

Electron paramagnetic resonance (EPR) spectroscopy is a powerful and widely used technique for studying structure and dynamics of biomolecules under bio-orthogonal conditions. In-cell EPR is an emerging area in this field; however, it is hampered by the reducing environment present in cells, which reduces most nitroxide spin labels to their corresponding diamagnetic N-hydroxyl derivatives. To d...

Journal: :Journal of medicinal chemistry 2014
Yutong Jiang Steven W Andrews Kevin R Condroski Brad Buckman Vlad Serebryany Steve Wenglowsky April L Kennedy Machender R Madduru Bin Wang Michael Lyon George A Doherty Benjamin T Woodard Christine Lemieux Mary Geck Do Hailong Zhang Joshua Ballard Guy Vigers Barbra J Brandhuber Peter Stengel John A Josey Leonid Beigelman Lawrence Blatt Scott D Seiwert

HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human innate immune system. Through structure-based drug design and optimization, macrocyclic peptidomimetic molecules bearing both a lipophilic P2 isoindoli...

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

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