it has been shown in some investigations that cardiovascular events are the main causes of death in hemodialysis patients. the exact etiology is unknown but some of the articles have reported a relation between aluminium ions in the dialysis solution and cardiovascular disorders. to determine the probable effect of aluminium on vasculature function, in vitro effects of aluminium ion on vasocons...

objective(s) four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. the effects of 5a and 5b on angiotensin receptors (at') and l-type calcium channels were investigated on isolated rat aorta. materials and methods aortic rings were pre-contracted with 1 pm angiotensin ii or 80 mm kcl and relaxant effects of losartan, nifedipine, 5a a...

the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

Introduction: Our previous studies showed that hydroalcoholic extract of leaf of Vitis vinifera relaxes the phenylephrine-induced contraction in rat thoracic aorta. This effect was dependent on endothelial integrity and NO-cGMP system. The vasorelaxant effect of extract was much lesser on KCl-induced contraction. We, therefore, postulated that K+ channels are involved. The main aim of the pr...