Background: Naturally extracted trans-(−)-kusunokinin from P. nigrum showed anticancer activities via binding and inhibition of CSF1R. However, the synthetic racemic mixtures trans-(−)- trans-(+)-kusunokinin (trans-(±)-kusunokinin) exhibited different effects on breast cancer cell lines. It was hypothesized that trans-(±)-kusunokinin bind to additional molecules, including AKR1B1. Previously, w...

— The bischelate monoanion [Fe((SCH2)2C6H4)2] 1_ contains an unconstrained, near-tetrahedral Fe(III)-S4 coordination unit (similar to the Fe-SU coordination unit occurring in rubredoxin proteins) and exhibits the Fe(III)/Fe(II) redox couple. Mossbauer parameters at 77 K are isomer shift S = 0.13 mm/s (relative to iron metal) and electric quadrupole splitting AZIQ = 0.57 mm/s. Application of an ...

— A new neptunium fluorozirconate glass (NpBasZrnF*) has been prepared and its Mossbauer spectrum was measured at 4.2 K and 77 K. Two resonance lines were observed. One is assigned to the Np ions occupying the normal Np sites in the compound. The other is thought to arise from Np which has replaced some of the Ba ions. The isomer shift of those ions suggests a configuration near 5f 6d . The Np ...

By means of ab-initio calculations on the basis of the FPLAPW method, we compared the energy loss near edge structure (ELNES) of carbon K edges in crystalline phenanthrene and its isomer, anthracene. In these two organic compounds, different non-equivalent carbon atoms can result in distinct K edge spectra due to the different carbon-carbon bond lengths, as a characteristic behavior of the mole...

ABSTRACT BACKGROUND Isotopic Ratio Outlier Analysis (IROA) is an untargeted metabolomics method that uses stable isotopic labeling and LC-HRMS for identification and relative quantification of metabolites in a biological sample under varying experimental conditions. OBJECTIVE We demonstrate a method using high-sensitivity 13C NMR to identify an unknown metabolite isolated from fractionated ma...

One of the easiest ways to start improving quality in a hospital is through clinical audit. Clinical audit is a quality improvement process that seeks to improve patient care and outcomes. It does this through a systematic process of review or evaluation against clearly defined criteria, followed by the implementation of change. Clinical audit is something that doctors, nurses, optometrists and...

Recoilless absorption spectra of the 21.6 keV gamma ray of IslEu in EuCu~Si2 and in EuRh2 reveal a single absorption line which has a strongly temperature dependent isomer shift. The recoilless absorption spectra in E ~ ~ L a l ~ R h 2 (0.075 < x < 0.5), Eu.125Pr.87~Rh2 and E u R h ~ ~ p t ~ (0.125 < x < 1) are composed of a few lines, many of which also exhibit strongly temperature dependent i...

We demonstrate the isomer-resolved spectroscopy of gas-phase ions, with different geometries separated prior to spectroscopic probe using ion mobility techniques. Specifically, ring and chain isomers of carbon cluster anions with 10;-12 atoms have been separated by ion mobility/mass spectrometry and examined by photoelectron spectroscopy. This methodology should also apply to other ion spectros...

XK469 (NSC 697887; (+/-)-2-[4-(7-chloro-2-quinoxaliny)oxy]phenoxy propionic acid), an analog of the herbicide Assure, which possesses antitumor activity, especially against murine solid tumors and human xenografts, has recently been found to be the first topoisomerase IIbeta poison. Both R(+) and S(-) isomers are cytotoxic, although the R-isomer is more potent. Using a chiral high-performance l...

The steam-distilled essential oil from Artemisia persica growing wild in Iran was analyzed by GC/MS. In all 50 compounds were identified; Davanone (60.56%), Cis Chrysanthenyl acetate (8.65%), Limonene (5.68%), ? Pinene (3.74%), Davanone ether isomer + (3.6%) and ? Thujene (3.6%) were the main components of the oil respectively.