نتایج جستجو برای: isoproterenol induced heart failure
تعداد نتایج: 1559566 فیلتر نتایج به سال:
The aim of the present study was to determine if renal sympathetic denervation (RSD) may alleviate isoproterenol-induced left ventricle remodeling, and to identify the underlying mechanism. A total of 70 rats were randomly divided into control (n=15), sham operation (n=15), heart failure (HF) with sham operation (HF + sham; n=20) and HF with treatment (HF + RSD; n=20) groups. The HF model was e...
BACKGROUND Head-upright tilt (HUT) testing is valuable in evaluating syncope. Isoproterenol is used to increase sensitivity. However, isoproterenol is contraindicated or dangerous in undiagnosed heart disease and produces false-positives. We introduced esmolol withdrawal during esmolol HUT, hypothesizing that (1) acute withdrawal of the ultrashort-acting beta-blocker induces beta-adrenergic eff...
Neer EJ (1973) The vasopressin-sensitive adenylate cyclase of the rat medulla. J Biol Chem 248: 4775-4781 Rona G, Chappel CI, Balazo T, Gaudry R (1959) An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 67: 443-455 Sayers G, Beall RJ, Seelig S (1972) Isolated adrenal cells: Adenocorticotrophic hormone, calcium, steroidogenesis, and...
Neer EJ (1973) The vasopressin-sensitive adenylate cyclase of the rat medulla. J Biol Chem 248: 4775-4781 Rona G, Chappel CI, Balazo T, Gaudry R (1959) An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 67: 443-455 Sayers G, Beall RJ, Seelig S (1972) Isolated adrenal cells: Adenocorticotrophic hormone, calcium, steroidogenesis, and...
Aims The benefit of the β1-adrenergic receptor (β1-AR) agonist dobutamine for treatment of acute heart failure in peripartum cardiomyopathy (PPCM) is controversial. Cardiac STAT3 expression is reduced in PPCM patients. Mice carrying a cardiomyocyte-restricted deletion of STAT3 (CKO) develop PPCM. We hypothesized that STAT3-dependent signalling networks may influence the response to β-AR agonist...
The purpose of the present study was to gain a better understanding of the relation between ventricular remodeling and heart failure by assessing the adaptation of the heart through time to graded myocardial injury in the presence of a patent coronary circulation. Left ventricular (LV) remodeling is a dynamic response of the heart to injury and a critical component in the development of heart f...
The preventive effects of (-) epicatechin on oxidative stress, cardiac mitochondrial damage, altered membrane bound adenosine triphosphatases and minerals were reported previously in isoproterenol-induced myocardial infarction model. Leakage of lysosomal glycohydrolases and cathepsins play an important role in the pathology of myocardial infarction. This study was aimed to evaluate the preventi...
The effect of alpha-tocopherol pretreatment on lipid peroxidation and antioxidant status in isoproterenol induced myocardial infarction was studied in rats. Isoproterenol administered rats showed a significant increase in lipid peroxides in serum, heart and aorta. A significant increase in serum iron level with a significant decrease in iron binding capacity was also observed. The levels of ant...
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